ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

More evidence for calorie restriction’s longevity effect

Vitamin D deficiency increases risk of chronic headache

Wearable biosensors can flag illness, Lyme disease, risk for diabetes; low airplane oxygen

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Glucocorticoid receptors, fibromyalgia (FM) & low back pain

  [ 17 votes ]   [ Discuss This Article ]
By Lentjes EG, Griep EN, Boersma JW, Romijn FP, de Kloet ER • www.ProHealth.com • November 5, 1997


Recently, fibromyalgia (FMS) was shown to be a disorder associated
with an altered functioning of the stress response system. FMS
patients display a hyperreactive pituitary adrenocorticotropic
hormone (ACTH) release in response to corticotropin-releasing
hormone (CRH) and to insulin-induced hypoglycemia. We
suggested that negative feedback of cortisol could be
deranged. Therefore we investigated the properties and
function of the glucocorticoid receptors (GR) in FMS patients
and compared the results with those of healthy persons and
patients with chronic low back pain (LBP a localized pain
condition). Forty primary FMS patients (F:M = 36:4), 28 LBP
patients (25:3) and 14 (12:2) healthy, sedentary control
persons were recruited for the study. Urinary free cortisol
excretion in FMS and LBP patients was lower compared to
controls. Only FMS patients displayed lower CBG and basal
serum cortisol concentrations when compared to controls.

However, plasma free cortisol concentrations were similar in
the three groups. There was no difference in the number of GR
per cell among the three groups (FMS: 6498 +/- 252, LBP: 6625
+/- 284, controls: 6576 +/- 304), but the dissociation
constant (Kd) of the FMS (14.5 +/- 0.9 nmol/l) and LBP (14.7
+/- 1.3 nmol/l) subjects was significantly higher than that of
the controls (10.9 +/- 0.8 nmol/l) (p < .05). The maximal
stimulation of the lymphocytes, as measured by the maximal
thymidine incorporation (in the absence of cortisol) in the
FMS group was approximately 1.5 times higher (p < .05) than in
the control or LBP group. The ED50 (the cortisol concentration
giving 50% inhibition of the thymidine incorporation),
however, was identical in all three groups. We conclude that
FMS patients have a mild hypocortisolemia, increased cortisol
feedback resistance in combination probably with a reduced CRH
synthesis or release in the hypothalamus. The role of the GR
and mineralocorticoid receptor (MR) in the CRH regulation in
the FMS patients remains to be solved.




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map