ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

More evidence for calorie restriction’s longevity effect

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

Mutations in the c-erbA beta 1 gene: do they underlie euthyroid fibromyalgia (FM)?

  [ 30 votes ]   [ Discuss This Article ]
By Lowe JC, Cullum ME, Graf LH Jr, Yellin J • www.ProHealth.com • February 15, 1997


Fibromyalgia, a chronic condition of widespread pain,
stiffness, and fatigue, has proven unresponsive to drugs, the
use of which is based on the 'serotonin-deficiency
hypothesis'. An alternative hypothesis-failed transcription
regulation by thyroid hormone-can explain the serotonin
deficiency and other objective findings and symptoms of
euthyroid fibromyalgia. Virtually every feature of
fibromyalgia corresponds to signs or symptoms associated with
failed transcription regulation by thyroid hormone.

In hypothyroid fibromyalgia, failed transcription regulation
would result from thyroid-hormone deficiency. In euthyroid
fibromyalgia, failed transcription regulation may result from
low-affinity thyroid hormone receptors coded by a mutated
c-erbA beta 1 gene, yielding partial peripheral resistance to
thyroid hormone. The hypothesis of this paper is that, in
euthyroid fibromyalgia, a mutant c-erbA beta 1 gene (or
alternately, the c-erbA alpha 1 gene) results in low-affinity
thyroid-hormone receptors that prevent normal thyroid hormone
regulation of transcription.

As in hypothyroidism, this would cause a shift toward
alpha-adrenergic dominance and increases in both cyclic
adenosine 3'-5'-phosphate phosphodiesterase and inhibitory
Gi proteins. The result would be tissue-specific hypothyroid-like
symptoms despite normal circulating thyroid-hormone levels.




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength FibroSleep™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map