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Immune responses associated with Chronic Fatigue Syndrome (CFS): a case-control study

  [ 18 votes ]   [ Discuss This Article ]
By Mawle AC, Nisenbaum R, Dobbins JG, Gary HE Jr, Stewart JA, Reyes M, Steele L, Schmid DS, Reeves WC • www.ProHealth.com • January 15, 1997


An exploratory case-control study was conducted to assess
whether the many reported differences in the immune function
of chronic fatigue syndrome (CFS) patients are detectable in
rigorously defined cases of CFS. Although many studies have
reported differences between cases and controls in various
measures of immune function, none of these differences were
found in all studies. In this study, no differences were
found in white blood cell numbers; immune complex,
complement, or serum immunoglobulin levels; delayed type
hypersensitivity and allergic responses; NK cell function;
and proliferative responses to mitogens and antigens.
Marginal differences were detected in cytokine responses
[MCM: IL-6 detected in 3 cases vs. 1 control; and TGF-beta in
3 cases vs. no controls] and in cell surface markers in the
total CFS population. However, when the patients were
subgrouped by type of disease onset (gradual or sudden) or by
how well they were feeling on the day of testing, more
pronounced differences were seen.




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