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Low Vitamin B12 and Genetic Disposition Increase Alzheimer's Risk

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www.ProHealth.com • April 5, 2004


Reported by Susan Aldridge, PhD, medical journalist (Health and Age) People who carry the ApoE4 gene variant and have low vitamin B12 levels do worse on memory tests. It’s already known that the ApoE4 gene variant is a risk factor for Alzheimer’s disease. And other research has revealed that low levels of vitamin B12 and folate can render someone more susceptible as well. Now researchers in London and Stockholm have looked at these two risk factors together. They studied a group of 167 older people in good health, checking them for blood vitamin levels and genetic status.

Those who had low vitamin B12 and carried the ApoE4 gene variant did worse on memory tests. They did not actually have dementia at this point, but maybe this poorer performance could be seen as a warning sign. Further research is now needed to see whether those with ApoE4 have more to gain from supplementation with vitamin B12 than those carrying other variants of this gene. Source: Neuropsychology April 2004 Volume 18 Number 2



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