ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

How Can You Benefit From Vitamin B12?

Calorie restriction promotes longevity through effects on mitochondrial network

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

What Is Bitter Orange?

Black Tea Is Great for Your Gut

Drug can dramatically reduce weight of people with obesity

Tryptophan's Possible Effects for Your Health

New Finding: Broccoli Helps Heal Leaky Gut

 
Print Page
Email Article

Significant Drop in Blood Pressure May Forecast Dementia in the Elderly

  [ 54 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 1, 2004


Source: American Heart Association DALLAS, July 2 –

A significant drop in systolic blood pressure may forewarn of Alzheimer's disease and dementia in some elderly people, according to a study reported in today's Stroke: Journal of the American Heart Association. A research team from Karolinska Institutet in Stockholm led by professor Laura Fratiglioni, M.D., Ph. D., found that a substantial drop in systolic blood pressure (the higher number in a blood pressure reading) predicted the onset of dementia in people with a systolic pressure of less than 160 millimeters of mercury (mm Hg).

A drop in systolic pressure of 15 mm Hg or more was linked to a three-fold increase in the risk of getting Alzheimer's disease or other dementia. The same 15 mm Hg or more decrease in patients who already had vascular disorders such as stroke and diabetes mellitus increased their risk of Alzheimer's 2.4 times, and 2.5 times for all types of dementia.

"Our findings imply that poor blood flow in the brain, resulting from an extensive decline in blood pressure, may promote the dementia process," said lead author Chengxuan Qiu, M.D., a postdoctoral epidemiologist at the Karolinska Institutet. However, because so few studies have addressed the connection between blood pressure decline and dementia, these findings need further verification. "Indeed, we have to consider that patients with dementia experience a decline in blood pressure some years before diagnosis, which continues to decline after the onset of dementia," Fratiglioni said.

Alzheimer's disease is the most common cause of dementia in Western countries. Other causes include repeated strokes and secondary dementia resulting from neurological disorders such as Parkinson's disease. Previous studies have shown that high blood pressure in midlife is associated with an increased risk of dementia and Alzheimer's disease later in life. However, studies investigating the link between dementia and blood pressure in late life have been conflicting. In a previous study, the Karolinska researchers suggested that both high and low blood pressure may damage cognitive abilities in the elderly.

This study aimed to verify blood pressure variations before and after dementia diagnosis, and to investigate whether blood pressure decline was predictive of Alzheimer's disease and dementia. Researchers examined 947 people age 75 or older who had no evidence of dementia when they entered a large study of aging and dementia conducted in the Kungsholmen district of Stockholm. Each participant had blood pressure measurements taken and physical examination done when they began the study and again three and six years later. Of these enrollees, 147 were diagnosed with Alzheimer's disease and 39 with other dementia at the three-year follow-up examination. At six years, researchers diagnosed another 91 with Alzheimer's and an additional 27 with other types of dementia.

"Our data show no substantial differences in blood pressure levels at enrollment between non-demented persons and those that were demented three to six years later," said co-author Bengt Winblad, M.D., Ph.D., professor of geriatric medicine at Karolinska Institutet and the principle investigator of the Kungsholmen project. "However, some elderly people who experience a significant decline in systolic blood pressure three to six years before diagnosis do have an increased risk of dementia and Alzheimer's disease."

"These findings indicate a possible threshold level in systolic pressure, especially for people with vascular disease in whom further reduction of blood pressure under this level may precipitate dementia onset," Qiu said. "Using antihypertensive medications is important for high blood pressure and related disorders, but our findings suggest that it is necessary to monitor these drugs in the very old to avoid a probable dangerous drop of blood pressure under a certain threshold."

American Heart Association spokesperson Daniel Jones, M.D. cautioned that the study doesn't mean high blood pressure in the elderly should be untreated. "The results of this study are of interest to the research community as we attempt to understand the complex relationship between blood pressure and dementia," Jones said. "However, data from well-conducted randomized clinical trials have consistently supported the view that treating systolic blood pressure to 140 mm Hg or less in the elderly is beneficial. No clinical trial data to date has indicated any adverse impact on cognitive function. Indeed, there is strong data from some studies that support the idea that lowering blood pressure prevents dementia."

The study did not specifically address how blood pressure might be related to the onset of dementia. However, the research team said scientific evidence indicates that high blood pressure is a risk factor for dementia and Alzheimer's disease, but continual or episodic low blood pressure may also increase the dementia risk by reducing blood flow to the brain. It is possible that subtle degeneration of cells in the blood-pressure-regulating centers of the brain – the sort of damage that elsewhere in the brain leads to dementia – may cause the pressure to fall. An extensive decline in blood pressure, in turn, may lead to a reduced blood flow in brain, which accelerates further the processes of dementia. "Therefore, blood pressure decline can be considered an accelerating factor of clinical dementia and Alzheimer's disease, rather than an initiator of the dementing process," the authors said.

Other co-authors are Eva von Strauss, Ph.D. Editor's note: For more on stroke, visit the American Stroke Association Web site: strokeassociation.org.



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Supercharge Your Brain with Two Powerful Nutrients Supercharge Your Brain with Two Powerful Nutrients
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map