ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Trimming the spare tire: Canola oil may cut belly fat

 
Print Page
Email Article

Research Points to Potential Obesity Treatment

  [ 45 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 12, 2004


Source: University of Denver Hormone causes body to metabolize stored fat DENVER --

In 1999, Drs. Miles Brennan and Ute Hochgeschewender announced their finding that melanocyte-stimulating hormone (MSH) regulates the balance of fat storage and metabolism. In April, they received a patent on the use of MSH analogs -- chemicals that mimic MSH -- as potential treatments for obesity (U.S. Patent #6,716,810).

Brennan is an associate research professor at the Eleanor Roosevelt Institute at the University of Denver (ERI) and Hochgeschwender is an associate member of the Oklahoma Medical Research Foundation. Their research also suggests that MSH integrates fat and glucose metabolism in the periphery, or body.

The scientists began by engineering mice missing the pro-opio melanocortin (POMC) gene. The mice, which had no MSH in their bloodstream, became obese because they stored all the fat they ate without metabolizing any of it. "We were then able to reduce their weight by adding MSH back into the peripheral circulation," says Brennan. "There are MSH receptors in essentially all peripheral tissues, and we know that mice treated with MSH experience an increase in the level of free fatty acids in the bloodstream. What we think happens is that MSH causes the adipocytes, or fat cells, to release free fatty acids, while other cells are stimulated to remove them from the bloodstream and burn them. Essentially it's a way to mobilize your stored fat for current needs."

The animals experienced no apparent ill effects with the weight loss. "The MSH has the highest activity when you have the highest level of excess weight," Brennan explains. "As the animal approaches normal weight, the effect plateaus out -- this is not going to be the anorexic's drug of choice, because when there's no more stored fat, you can't change the balance. We think it's got significant potential for obesity therapies."

MSH research pioneer Victor Hruby, agrees. "It's clear that the POMC gene and its products are involved in additional ways that Miles and his colleagues have discovered, such as feeding behavior and energy homeostasis. It continues to be an evolving, exciting story that has many implications for human health. I think they are on to something worth pursuing."

The Regents Professor in the University of Arizona Department of Chemistry, Hruby also is a professor of neuroscience, biochemistry and molecular biophysics at the university and the Arizona Research Laboratory. He and his collaborators began studying MSH in the 1970s, and have developed several hundred derivatives of the hormone over the past 35 years. "I tell my students we're living in a revolutionary time," he says. "Who knows what we'll discover tomorrow, because it's clear there are lots of unknowns. It gets more exciting all the time, and I feel almost like I'm starting over again."

The next step is licensing the discovery and working with a pharmaceutical company to develop and test clinical therapies. Previously, Brennan and Hochgeschwender, who have collaborated since 1986, have patented mice with a range of genetic modifications to the POMC gene (U.S. Patent # 6,603,058), and a method of reducing insulin resistance (U.S. Patent #6,689,938) that could lead to potential treatments for diabetes accompanying obesity.

Denver's Eleanor Roosevelt Institute (ERI) was founded in 1961 as a private, independent research center. ERI merged with the University of Denver in 2003. The Institute is staffed by leading scientists from around the world who study Down syndrome, Lou Gehrig's disease, cancer, obesity, type II diabetes and other diseases and conditions. It is the mission of the Institute's scientists to seek an in-depth understanding of the process of life and through this understanding, work towards unlocking the mysteries of human health and disease.



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra EPA  - Fish Oil FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map