ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Can Magnesium Relieve Your Tinnitus?

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Restoring NAD+ could reduce DNA damage accumulation

 
Print Page
Email Article

Collagen crosslinks in fibromyalgia (FM)

  [ 20 votes ]   [ Discuss This Article ]
By Sprott H, Muller A, Heine H • www.ProHealth.com • August 6, 1997


OBJECTIVE: To determine if abnormal collagen metabolism is a
characteristic of fibromyalgia.

METHODS: The diagnosis of
fibromyalgia was made according to the American College of
Rheumatology criteria. Skin biopsy samples were obtained from
the trapezius region of 8 patients with fibromyalgia. Urine
was collected under standardized conditions from 55 control
subjects and 39 patients with fibromyalgia, and serum was
obtained from 17 controls and 22 patients with fibromyalgia.

Pyridinoline (Pyd), an indicator of connective tissue disease,
and deoxypyridinoline (Dpyd), an indicator of bone
degradation, both of which represent products of lysyl
oxidase-mediated crosslinking in collagen, were analyzed by
ion-paired and gradient high-performance liquid chromatography
(HPLC) methods with fluorescence detection. Levels of
hydroxyproline (Hyp), a collagen turnover marker, were also
measured. The findings were related to creatinine levels, and
the Pyd:Dpyd ratio was determined.

RESULTS: Highly ordered
cuffs of collagen were observed around the terminal nerve
fibers by electron microscopic examination of biopsy tissue
from all 8 patients with fibromyalgia, but were not observed
in any of the control skin samples. The Pyd:Dpyd ratios in the
urine and serum and the Hyp levels in the urine were
significantly lower in patients with fibromyalgia than in
healthy controls.

CONCLUSION: Decreased levels of collagen
crosslinking in fibromyalgia may contribute to remodeling of
the extracellular matrix and collagen deposition around the
nerve fibers, and may contribute to the lower pain threshold
at the tender points. Analysis of altered collagen metabolism
either by histologic examination on biopsy, or preferably, by
HPLC analysis of collagen metabolites in urine or serum may
aid in understanding more about the pathogenesis of
fibromyalgia.




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® FibroSleep™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map