ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Curcumin: The All In One Solution, Part 2

CoQ10 — A Nutritional Powerhouse for Mitochondrial Health

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Use Burdock Oil to Promote Healthy Hair Growth

Why You Should Take Your Apple Cider Vinegar at Night

AMA journal associates iron deficiency with hearing loss

Lutein linked to preservation of crystallized intelligence

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

 
Print Page
Email Article

Collagen crosslinks in fibromyalgia (FM)

  [ 20 votes ]   [ Discuss This Article ]
By Sprott H, Muller A, Heine H • www.ProHealth.com • August 6, 1997


OBJECTIVE: To determine if abnormal collagen metabolism is a
characteristic of fibromyalgia.

METHODS: The diagnosis of
fibromyalgia was made according to the American College of
Rheumatology criteria. Skin biopsy samples were obtained from
the trapezius region of 8 patients with fibromyalgia. Urine
was collected under standardized conditions from 55 control
subjects and 39 patients with fibromyalgia, and serum was
obtained from 17 controls and 22 patients with fibromyalgia.

Pyridinoline (Pyd), an indicator of connective tissue disease,
and deoxypyridinoline (Dpyd), an indicator of bone
degradation, both of which represent products of lysyl
oxidase-mediated crosslinking in collagen, were analyzed by
ion-paired and gradient high-performance liquid chromatography
(HPLC) methods with fluorescence detection. Levels of
hydroxyproline (Hyp), a collagen turnover marker, were also
measured. The findings were related to creatinine levels, and
the Pyd:Dpyd ratio was determined.

RESULTS: Highly ordered
cuffs of collagen were observed around the terminal nerve
fibers by electron microscopic examination of biopsy tissue
from all 8 patients with fibromyalgia, but were not observed
in any of the control skin samples. The Pyd:Dpyd ratios in the
urine and serum and the Hyp levels in the urine were
significantly lower in patients with fibromyalgia than in
healthy controls.

CONCLUSION: Decreased levels of collagen
crosslinking in fibromyalgia may contribute to remodeling of
the extracellular matrix and collagen deposition around the
nerve fibers, and may contribute to the lower pain threshold
at the tender points. Analysis of altered collagen metabolism
either by histologic examination on biopsy, or preferably, by
HPLC analysis of collagen metabolites in urine or serum may
aid in understanding more about the pathogenesis of
fibromyalgia.




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map