ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Safely Reduce a Common Cause of Stomach Distress

 
Print Page
Email Article

Range of antinuclear antibodies in "healthy" individuals compared with that in patients with Lupus, Scleroderma, RA

  [ 94 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 8, 1997


OBJECTIVE: To determine the range of antinuclear antibodies
(ANA) in "healthy" individuals compared with that in patients
with systemic lupus erythematosus (SLE), systemic sclerosis
(SSc; scleroderma), Sjogren's syndrome (SS), rheumatoid
arthritis (RA), or soft tissue rheumatism (STR).

METHODS:
Fifteen international laboratories experienced in performing
tests for ANA by indirect immunofluorescence participated in
analyzing coded sera from healthy individuals and from
patients in the 5 different disease groups described above.
Except for the stipulation that HEp-2 cells should be used as
substrate, each laboratory used its own in-house methodology
so that the data might be expected to reflect the output of a
cross-section of worldwide ANA reference laboratories. The
sera were analyzed at 4 dilutions: 1:40, 1:80, 1:160, and
1:320.

RESULTS: In healthy individuals, the frequency of ANA
did not differ significantly across the 4 age subgroups
spanning 20-60 years of age. This putatively normal population
was ANA positive in 31.7% of individuals at 1:40 serum
dilution, 13.3% at 1:80, 5.0% at 1:160, and 3.3% at 1:320. In
comparison with the findings among the disease groups, a low
cutoff point at 1:40 serum dilution (high sensitivity, low
specificity) could have diagnostic value, since it would
classify virtually all patients with SLE, SSc, or SS as ANA
positive. Conversely, a high positive cutoff at 1:160 serum
dilution (high specificity, low sensitivity) would be useful
to confirm the presence of disease in only a portion of cases,
but would be likely to exclude 95% of normal individuals.

CONCLUSION: It is recommended that laboratories performing
immunofluorescent ANA tests should report results at both the
1:40 and 1:160 dilutions, and should supply information on the
percentage of normal individuals who are positive at these
dilutions. A low-titer ANA is not necessarily insignificant
and might depend on at least 4 specific factors. ANA assays
can be a useful discriminant in recognizing certain disease
conditions, but can create misunderstanding when the
limitations are not fully appreciated.

Tan EM, Feltkamp TE, Smolen JS, Butcher B, Dawkins R, Fritzler MJ, Gordon T, Hardin JA, Kalden JR, Lahita RG, Maini RN, McDougal JS, Rothfield NF, Smeenk RJ, Takasaki Y, Wiik A, Wilson MR, Koziol JA




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map