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Consequences of live poliovirus vaccine administration in Chronic Fatigue Syndrome (CFS)

  [ 9 votes ]   [ Discuss This Article ]
By Vedhara K, Llewelyn MB, Fox JD, Jones M, Jones R, Clements GB, Wang EC, Smith AP, Borysiewicz LK • www.ProHealth.com • May 13, 1997


The effect of live oral polio virus vaccination on chronic
fatigue syndrome (CFS) patients was examined in a double-blind
study. CFS patients were allocated randomly to placebo (N =
7) or vaccine (N = 7) conditions. All controls subjects
received the vaccine (9). Vaccine administration was not
associated with clinical exacerbation of CFS. However,
objective responses to the vaccine revealed differences
between patients and controls: increased poliovirus
isolation, earlier peak proliferative responses, lower T-cell
subsets on certain days post vaccination and a trend for
reduced gamma-interferon in the CFS-vaccine group. Polio
vaccination was not found to be clinically contraindicated in
CFS patients, however, there was evidence of altered immune
reactivity and virus clearance.




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