ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

CoQ10's Potential Capabilities for Your Health

Testosterone replacement therapy associated with improved urinary, sexual function

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

The Many Potential Health Benefits of Curcumin

8 Chia Seed Recipes

 
Print Page
Email Article

Duke Chemists Isolating Individual Molecules of Toxic Protein in Alzheimer's, Parkinson's Disease

  [ 458 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 23, 2005


SAN DIEGO, Calif., March 16 (AScribe Newswire) -- To understand the formation of the brain-clogging deposits that cause such disorders as Alzheimer's and Parkinson's diseases, Duke University chemists have figured out how to capture and "micromanipulate" the single molecular building blocks of the deposits. Their aim is to understand the detailed assembly process for the toxic protein called amyloid plaque. Such basic understanding, they said, could lead to approaches to preventing plaque formation. The researchers led by Boris Akhremitchev are using the infinitesimal tip of a customized atomic force microscope (AFM) to capture, isolate and study single molecules, called monomers, that are the building blocks of the toxic protein polymers known as amyloid fibrils. Atomic force microscopes use a sharp microscopic tip to image surfaces and detect energy differences by mechanically probing molecular surfaces. In a poster presentation at the American Chemical Society's annual meeting, the researchers will describe the first biophysical analysis of interactions between monomers that form the amyloid fibrils associated with Parkinson's disease. This presentation will include studies by Chad Ray, a graduate student in Akhremitchev's research group, that clarify the nature of binding forces between amyloid molecules. The poster session will take place March 16, 2005, 7:30 - 10 p.m. Pacific Standard Time, in Hall D of the San Diego Convention Center. This work was funded by the Camille and Henry Dreyfus Foundation and by Duke University. It has been difficult to study the chemistry of formation of these fibrils within the brains of humans and other animals, said Akhremitchev, who is an assistant professor of chemistry. In the brain, "monomers of all kinds are suspended in a soup in equilibrium," he said. Given that the components of amyloid fibrils measure only billionths of a meter and are floating in a disordered mix, "the initial stages of amyloid aggregation are not fully understood," he said. "When you start a normal reaction, molecules are free in solution so they interact with each other randomly," Akhremitchev said. "If you want to dissect the process, you would rather want to study interactions individually." Thus, the Duke chemists capture individual monomers at the end of long chained polyethylene glycol molecules. They then attach one such tethered monomer to a microscope slide and the other to the AFM microscope tip. They can then bring the isolated and suspended molecules together to study how and whether they interact. The Duke researchers study these interactions by retracting the tip of their AFM, which can measure changes in force at the atomic scale. Pulling back the tip can induce a measurable tug on the chemical bonds that hold together the two elevated monomers. By pulling on such bonds, the Duke scientists can deduce how much energy was required to bring the molecules together. Then, using their knowledge of protein chemistry, they can develop hypotheses about how those particular monomers might, or might not, be involved in the evolution of fibrils, They can thus develop a better understanding of amyloid aggregation. The scientists are also seeking the precise point during fibril formation when interactions between monomers become irreversible. Defining that point is important because "the fibrils are virtually indestructible once formed," he said. "How all these monomers interact to form these amyloid fibrils is just not known at this point," said Akhremitchev. "And that is why it is such a great challenge. That's what we want to learn."



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra EPA  - Fish Oil Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Breaking Through the Mental Fog Breaking Through the Mental Fog
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map