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Double-blind, placebo-controlled cross-over study of intravenous -adenosyl-L-methionine in patients with fibromyalgia (FM)

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By Volkmann H, Norregaard J, Jacobsen S, Danneskiold-Samsoe B, Knoke G, Nehrdich D • www.ProHealth.com • March 10, 1997


The objective of this study was to test the efficacy of
intravenously administered S-adenosyl-L-methionine (SAMe) in
patients with fibromyalgia (FM). Thirty-four out-patients with
fibromyalgia symptoms received SAMe 600 mg i.v. or placebo
daily for 10 days in a cross-over trial. There was no
significant difference in improvement in the primary outcome:
tender point change between the two treatment groups. There
was a tendency towards statistical significance in favour of
SAMe on subjective perception of pain at rest (p = 0.08), pain
on movement (p = 0.11), and overall well-being (p = 0.17) and
slight improvement only on fatigue, quality of sleep, morning
stiffness, and on the Fibromyalgia Impact Questionnaire for
pain. No effect could be observed on isokinetic muscle
strength, Zerrsen self-assessment questionnaire, and the face
scale. No effect of SAMe in patients with FM was found in this
short term study.




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