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The cognitive, subjective, & physical effects of a ginkgo biloba/panax ginseng combination in healthy volunteers with neurasthenic complaints

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By Wesnes KA, Faleni RA, Hefting NR, Hoogsteen G, Houben JJ, Jenkins E, Jonkman JH Leonard J, Petrini O, van Lier JJ • www.ProHealth.com • March 10, 1997


We evaluated the effects of a Ginkgo biloba/ginseng
combination on cognitive function in this 90-day,
double-blind, placebo-controlled, parallel-group study.
Sixty-four healthy volunteers (aged 40 to 65 years), selected
on the basis of fulfilling the ICD-10 F48.0 criteria for
neurasthenia, were assigned randomly to four equal dosing
groups, receiving 80, 160, or 320 mg of the combination b.i.d.
or placebo. Assessments were performed on the day before
dosing, and again at Days 1, 30, and 90 at 1 hour after the
morning dose and 1 hour after the afternoon dose. The
assessments included the Cognitive Drug Research (CDR)
computerized assessment system, the Vienna Determination Unit,
cycle ergometry, and various questionnaires. The treatments
were well tolerated by all volunteers. On Day 90 at 1 hour
post morning dosing, dose-related improvements were seen on
the CDR tests, the 320 mg dose being significantly superior to
placebo. These effects, however, were reversed 1 hour after
the afternoon dose, possibly suggesting that a longer
inter-dosing interval would be preferable. The 80-mg dose
produced a significant benefit on the ergometry assessment of
heart rate at maximum load. There were also several supporting
changes from other assessments, including an advantage of 320
mg over placebo on the global score from the Symptom
Checklist-90-revised (SCL-90-R) at Day 90.




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