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Yale-Griffin Prevention Research Center to Study Effects of Chromium Picolinate in People with Pre-Diabetes

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www.ProHealth.com • August 2, 2004


NIH-funded Clinical Trial to Evaluate Potential Benefit of Nutritional Supplements on Blood Glucose & Heart Health DERBY, Conn., July 22 /PRNewswire/ -- The Yale-Griffin Prevention Research Center (PRC), a collaboration between Griffin Hospital and the Yale School of Epidemiology and Public Health, announced the start of a double-blind, randomized, placebo-controlled clinical trial to study the effects of chromium supplementation on blood glucose levels and endothelial function in people with pre-diabetes. The two-year pilot study is funded by a grant from the National Institutes of Health's (NIH) National Center for Complementary and Alternative Medicine (NCCAM). "The aim of this clinical trial is to further explore the benefit of nutritional intervention with chromium picolinate, before pre-diabetes progresses into a chronic disease state," explains Dr. David Katz, director of the Yale-Griffin Prevention Research Center and principal investigator of the new study. "In pre-diabetes, pharmacotherapy may not yet be justified or acceptable for patients. Chromium has shown potential to serve as a safe and affordable adjunct nutritional therapy, as part of a preventive approach." Pre-diabetes, also known as Impaired Glucose Tolerance (IGT), affects approximately 41 million Americans and is a pre-cursor to type 2 diabetes and cardiovascular disease. The American Diabetes Association (ADA) defines pre- diabetes as a condition where blood sugar levels are higher than normal, but not high enough to be diagnosed as type 2 diabetes. Study Design: Sixty (60) patients will include adult men and women, who have been identified as "pre-diabetic". The study will compare the effects of 500 mcg and 1,000 mcg of chromium picolinate daily on glucose tolerance, compared with a placebo control group. Glucose tolerance will be measured by fasting insulin and 2-hour post 75 g oral glucose tolerance test (OGTT). People with pre-diabetes have a 1.5-fold risk of cardiovascular disease compared to people with normal blood glucose. Importantly, the study will also measure the effects of chromium supplementation on endothelial function, a marker of vascular health and heart disease risk. Endothelial function will be measured by an ultrasound test of the brachial artery in the arm, a non- invasive procedure. A number of studies have shown that chromium in the form of chromium picolinate helps reduce insulin resistance, improve blood sugar control, and may help reduce risk of cardiovascular disease and type 2 diabetes. "Chromium picolinate was selected for this study, because it is the most commonly used and chemically stable form of the mineral," according to Dr. Katz. Nutrition 21 will supply Chromax(R) chromium picolinate for the clinical trial. Yale-Griffin Prevention Research Center The Yale-Griffin Prevention Research Center (PRC) was established in 1998 through a 5-year, nearly $3 million grant from the Centers for Disease Control (CDC). One of 28 such centers nationwide, each of which represents an academic/community partnership, the Yale-Griffin PRC is the only center in the network based in a hospital. The PRC is committed to research pertaining to the primary, secondary, & tertiary prevention of chronic disease that is responsive to the priorities of local residents in the Lower Naugatuck Valley of CT, the residents of Connecticut's major cities, and other communities throughout the state. The center is dedicated to participatory research methods, to a robust research agenda inclusive of developmental/determinant, intervention, and translational research; to community involvement in public health; to the eradication of disparities in health and health care in the communities served; and to the dissemination of effective interventions in support of the national objectives of Healthy People 2010. SOURCE Yale-Griffin Prevention Research Center



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