ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

What’s Fenugreek Good For?

Print Page
Email Article

FDA Approves Azulfidine EN-Tabs (Sulfasalazine) To Treat Rheumatoid Arthritis In Children

  [ 19 votes ]   [ Discuss This Article ] • October 3, 2000

Children with juvenile rheumatoid arthritis involving five or more diseased joints, can turn to a newly approved drug for treatment. The U.S. Food and Drug Administration (FDA) has approved a new indication for Azulfidine EN-tabs® (sulfasalazine delayed release tablets) in patients who have responded inadequately to salicylates or other nonsteroidal anti-inflammatory drugs (NSAIDs).

Azulfidine EN-tabs is the only formulation of sulfasalazine approved by the FDA for the treatment of both juvenile and adult RA. The enteric-coated formulation of Azulfidine EN-tabs was specifically designed to reduce the likelihood of nausea and stomach upset.

In a randomized, double-blind, placebo-controlled, clinical trial, sulfasalazine was evaluated in children with juvenile rheumatoid arthritis. This 24-week trial showed that sulfasalazine, compared to placebo, significantly reduced several clinical endpoints of joint disease including number and severity of swollen joints, number of active joints and overall joint severity score.

This clinical effectiveness of sulfasalazine was reinforced by significant reduction in disease activity scored by physicians, parents and patients.

"The FDA's approval of Azulfidine EN-tabs for juvenile rheumatoid arthritis gives clinicians in pediatric rheumatology an important new option to effectively manage this condition," said Arthur Weaver, M.D., director of clinical research at The Arthritis Center of Nebraska, and clinical professor at the University of Nebraska Medical Center.

In the treatment of adult RA, sulfasalazine, the active ingredient in Azulfidine EN-tabs, has been classified by the American College of Rheumatology as part of a group of compounds called disease-modifying anti-rheumatic drugs (DMARDs). While it has not been confirmed in children, DMARDs have the potential to reduce or prevent joint damage and preserve joint integrity and function. Rheumatoid Arthritis is a debilitating disease that affects 2.1 million Americans, of which 50,000 are children. The disease causes joint pain, stiffness and swelling in or around joints, as well as joint destruction.

Patients with intestinal or urinary obstructions, porphyria (pigment disorder) or hypersensitivity to sulfasalazine, sulfonamides or salicylates, should not use Azulfidine EN-tabs. The most common adverse reactions (incidence of 5 percent or greater) reported in RA clinical trials with sulfasalazine enteric-coated tablets were nausea, dyspepsia, rash, immunoglobulin suppression, headache, abdominal pain, vomiting and fever.

Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Safely Burn Away Body Fat Safely Burn Away Body Fat
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map