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Clinical & neurocognitive features of the post Lyme syndrome

  [ 93 votes ]   [ 1 Comment ]
By Bujak DI, Weinstein A, Dornbush RL • www.ProHealth.com • August 12, 1996


OBJECTIVE: To evaluate neurocognitive impairment in patients with
persistent arthralgia, fatigue, and subjective memory loss in
patients after Lyme disease (post-Lyme syndrome, PLS).
METHODS: We compared the clinical, neurocognitive, and
psychological features of 23 patients with PLS to 23 age,
sex, and education matched recovered patients (REC). All met
Centers for Disease Control criteria for Lyme disease, were
ELISA positive at onset of Lyme disease and were previously
treated with standard antibiotic regimens.
RESULTS: Of the
patients with PLS, 7 (30%) had fibromyalgia (FM), 3 (13%) had
chronic fatigue syndrome, and 10 (43%) had similar but milder
symptoms but did not meet the criteria for either. 22 of 23
patients with PLS complained of decreased memory or
concentration problems. Patients with PLS had significantly
lower scores on the attention/concentration scale (p = 0.012)
of the Wechsler Memory Scale-Revised (WMS-R), indicating
lowered attention/concentration. 52% of patients with PLS and
35% in the REC group had significantly lower (p < 0.05) WMS-R
verbal memory scores than visual memory scores. The PLS group
had subjectively more problems with sleep and mood changes and
higher scores on several scales of Symptom Check List 90-R (p
< 0.01), indicating greater physical distress. Beck
Depression Inventory scores were also higher for the PLS than
the REC group (p < 0.005), but were within the normal range.
CONCLUSION: Despite antibiotic treatment, a sequelae of Lyme
disease may be a PLS characterized by persistent arthralgia,
fatigue, and neurocognitive impairment that is probably
induced by Lyme disease.




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Article Comments Post a Comment

Sample selection poor at best
Posted by: lyme
Apr 2, 2008
The sample selection is very bad choice of controls. A better criteria for controls would be someone that never had lyme disease and that had 0 western blot band showing positive. Garbage in garbage out on this study.
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