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Evidence that abnormalities of central neurohormonal systems are key to understanding fibromyalgia (FM) & Chronic Fatigue Syndrome (CFS)

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By Crofford LJ, Demitrack MA • www.ProHealth.com • May 6, 1996


Fibromyalgia (FM) and chronic fatigue syndrome (CFS) fall into the
spectrum of what might be termed stress-associated syndromes
by virtue of frequent onset after acute or chronic stressors
and apparent exacerbation of symptoms during periods of
physical or emotional stress. These illnesses also share
perturbation of the hypothalamic-pituitary-adrenal axis and
sympathetic stress response systems. In this article, the
authors discuss the specific neurohormonal abnormalities found
in FM and CFS and potential mechanisms by which dysfunction
of neurohormonal stress-response systems could contribute to
vulnerability to stress-associated syndromes and to the
symptoms of FM and CFS.




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