ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Meta-analysis links vitamin D deficiency with increased risk of mortality during 10.5 year median pe...

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Valerian Root Help You Sleep Better?

Can Ginkgo Give Your Brain a Boost?

Fighting Statin-Induced Diabetes with CoQ10

Eight servings of veggies a day is clearly best for the heart

The Many Wonders of Calming Sandalwood Oil

Curcumin — A Novel Treatment Alternative for Depression

 
Print Page
Email Article

Specificity & dosimetry of toxicologic responses

  [ 24 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 15, 1996


Toxicology has two goals. The first is to identify and characterize
the adverse effects that can be produced in biological systems
by exposure to chemicals and the second is to use this
information to predict the type and severity of responses in
other species and exposure situations. The tools that the
toxicologist uses to detect and describe the adverse effects
of chemical exposure include the traditional acute,
subchronic, and chronic studies in animals plus a variety of
special studies designed to demonstrate specific organ
damage, reproductive and teratogenic effects, neurotoxicity,
immunotoxicity, genotoxicity, and other responses. These are
often supplemented with studies of the kinetics and the
mechanism of action and more recently with studies designed to
elucidate the molecular basis for cancer and other effects.
Theses studies together with the information on exposure
provide the basis for subsequent toxicologic predictions.
Although general effects such as weight loss and mortality
are included in toxicity protocols, most of the toxicology
tests are related to specific end-organ toxicity or to
mechanism or behavioral studies. We do not have animal
protocols to study individually the subjective symptoms
described for multiple chemical sensitivity, such as
depression, fatigue, headache, and memory loss, and our tests
lack sufficient specificity to evaluate a syndrome which is
composed primarily of such symptoms. Since all chemicals can
produce adverse effects under some conditions of exposure,
toxicologic predictions are most useful when they specify
both the type of adverse effect anticipated and the dose
required to produce the effect. Multiple chemical sensitivity
does not appear to consistently involve specific chemicals or
specific adverse effects and the effects observed are
reported to lack evidence of a threshold and to occur at
extremely low levels. It is difficult to include these
parameters in any reasonable toxicologic prediction relating
cause and response in multiple chemical sensitivity or
similar conditions.

Doull J




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra EPA  - Fish Oil FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map