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Explaining fatigue in congestive heart failure

  [ 21 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 10, 1996


Fatigue is a prominent symptom in patients with chronic heart
failure, limiting physical activity and impairing quality of
life. Although the underlying mechanisms are not clearly
identified, alterations associated with peripheral adaptation
in heart failure appear to play an important role, including
a variably impaired peripheral perfusion during exercise,
reduced oxidative capacity of skeletal muscle, impaired
muscle strength, and possibly reflex mechanisms associated
with alterations in the metabolism of skeletal muscle.
Exercise training can, in part, reverse these peripheral
alterations, improve exercise capacity, and alleviate
fatigue.

Drexler H, Coats AJ




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