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Comparison of 99m Tc HMPAO SPECT scan between Chronic Fatigue Syndrome (CFS), major depression & healthy controls: an exploratory study of clinical correlates of regional cerebral blood flow

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www.ProHealth.com • March 20, 1996


An explorative analysis of the relationship between
symptomatology and cerebral blood flow in the chronic fatigue
syndrome (CFS) as assessed with 99mTc HMPAO SPECT scan reveals
statistically significant positive correlations between
frontal blood flow on the one hand and objectively and
subjectively assessed cognitive impairment, self-rating of
physical activity limitations and total score on Hamilton
Depression Rating Scale on the other. A pathophysiological
role of frontal blood flow in the cognitive impairment and
physical activity limitations in CFS is hypothesized. A
comparison of cerebral blood flow between CFS, major
depression (MD) and healthy controls (HC) has been performed.
A lower superofrontal perfusion index is demonstrated in MD as
compared with both CFS and HC. There is neither a global nor a
marked regional hypoperfusion in CFS compared with HC.
Asymmetry (R > L) of tracer uptake at parietotemporal level is
demonstrated in CFS as compared with MD.

Fischler B, D'Haenen H, Cluydts R, Michiels V, Demets K, Bossuyt A,
Kaufman L, De Meirleir K




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