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A guide to the understanding & use of tricyclic antidepressants in the overall management of fibromyalgia (FM) & other chronic pain syndromes

  [ 53 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 27, 1996


The purpose of this review is to present relatively detailed
information on the characteristics of tricyclic
antidepressants, mainly amitriptyline hydrochloride and
doxepin hydrochloride, for use as an integral part of the safe
and effective management of fibromyalgia and, to a lesser
extent, other chronic pain syndromes. Data sources include
MEDLINE searches in English, relevant reference books and
textbooks, my personal database and library, as well as
personal clinical experience. I discuss these data with regard
to the pharmacologic characteristics, mechanisms of action,
adverse effects, and precautions involved with the use of
tricyclic antidepressants. Additional information is given on
drug selection and dosage titration. Much emphasis is placed
on the fact that while tricyclic antidepressants play a major
role in the management of fibromyalgia and other chronic pain
syndromes, lifestyle alterations (eg. physical reconditioning
and exercise), as well as behavior modification, are also
vital to a successful outcome in management. [References: 44]

Godfrey RG




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