ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Get the Most From Your Green Tea

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

The management of treatment-resistant depression in disorders on the interface of psychiatry & medicine. Fibromyalgia (FM), Chronic Fatigue Syndrome (CFS), migraine, irritable bowel syndrome, atypical facial pain, & premenstrual dysphoric disorder

  [ 45 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 10, 1996


We have reviewed studies examining the efficacy of various
psychotropic medications, primarily antidepressant agents, in
the treatment of a group of disorders that appear to exhibit
some phenomenologic and genetic relationship to major
depression. These disorders all appear to benefit (albeit to
varying degrees) from antidepressant medications of several
different chemical families. This observation has important
theoretical and clinical implications. From a theoretical
perspective, these results invite the hypothesis that these
various disorders may share some particular etiologic "step"
in common with major depression-and that the various
antidepressant classes benefit these various disorders and
major depression via a common action at this hypothetical
"step". Although there is an appealing parsimony to this
hypothesis, several reservations must be considered. First, it
must be recognized that the quality of the available studies
varies widely. As noted in the text, these studies used
numerous different designs, varying diagnostic criteria for
the disorders under study, and diverse methods of rating
outcome. Interpretation is further complicated by the fact
that many studies included other concomitant medications or
therapeutic interventions in addition to the psychotropic
drugs administered. Also, the dose of antidepressant
medications administered in many of these studies, especially
those using TCAs, was often much less than that normally
administered in the treatment of major depressive disorder
itself. Finally, many of the studies did not systematically
evaluate improvement in both the physical and psychological
symptoms of a given disorder. For all of these reasons, any
theoretic discussion of the results must be tentative.
Nevertheless, the overall tally of results strongly favors the
hypothesis that antidepressant agents, regardless of their
chemical class, are generally useful in the treatment of these
disorders. At a minimum, therefore, we can conclude that
antidepressant treatment in these disorders deserves
aggressive further investigation in studies with modern,
rigorous designs. Second, even allowing that multiple
antidepressant agents are effective in these various
disorders, it still may be premature to conclude that these
disorders are related to major depressive disorder. In
particular, many of the studies found little correlation
between improvement in psychological symptoms and physical
symptoms of a given disorder. This observation would seem to
argue against a relationship with major depressive disorder.
The alternative hypothesis, however, namely, that these
disorders do not share a common etiologic "step," seems even
less attractive. It would be a remarkable coincidence if, say,
fluoxetine possessed an antidepressant property, an
independent antimigraine property, and a third, independent,
antipremenstrual dysphoric disorder property. And it would be
even more peculiar if various other antidepressant medications
chemically unrelated to fluoxetine also, by chance alone,
benefited all of these same disorders via still other
independent mechanisms. Although we cannot, of course, rule
out the possibility of multiple mechanisms and multiple
causes, the experience of scientific research often has been
that the simpler explanation of a phenomenon has proved to be
correct. Therefore, the possibility of a link among these
various antidepressant-responsive disorders deserves
investigation. From a clinical perspective, too, these results
are important. They suggest that trials of antidepressant
medications should be strongly considered in patients with
these disorders. Furthermore, other types of psychotropic
medication appear to have a role in the treatment of
individual disorders, as discussed in the corresponding
sections. In summary, the management of patients with
fibromyalgia, chronic fatigue syndrome, migraine, irritable
bowel syndrome, atypical facial pain, and premenstrual
dysphoric disorder is often d [References: 79]

Gruber AJ, Hudson JI, Pope HG Jr




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® FibroSleep™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map