ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

What’s Fenugreek Good For?

Print Page
Email Article

Brain Abnormality Found In Alzheimer’s Disease Related to Gait Impairment in Older Persons

  [ 333 votes ]   [ Discuss This Article ] • January 25, 2006

Source: Rush University Medical Center Results Suggest Alzheimer's Disease May Be More Common than Previously Recognized CHICAGO - A new study from Rush University Medical Center helps explain why gait problems are often progressive in old age and related to risk of dementia and death. The study, published in the January issue of the Annals of Neurology, found that neurofibrillary tangles in the substantia nigra, a part of the brain that is subject to cell loss in Parkinson's disease, are associated with gait impairment in older persons with and without dementia. Neurofibrillary tangles are a classic brain abnormality seen in Alzheimer's disease. The more tangle pathology in the substantia nigra, the more impaired the person's gait was before death. "Older persons without Parkinson's disease often exhibit parkinsonian signs, such as difficulty with walking and balance (gait impairment), slowness in movements, rigidity and tremor," said study author Dr. Julie Schneider of the Rush Alzheimer's Disease Center. "The mild parkinsonian signs associated with aging have been historically viewed simply as an expected sign of aging rather than a disease process. Previous studies have shown that at least one of these signs, gait impairment, has harmful effects in older persons, and our current study suggests why this may be the case." The study included 86 autopsied subjects from the Religious Orders Study, a longitudinal clinical-pathological study of aging and dementia. Participants of the Religious Orders Study are older Catholic clergy who enroll without known dementia and agree to annual follow-up and brain donation at death. The study included persons with and without dementia but excluded people with idiopathic Parkinson's disease. Though less than half of the subjects had dementia, the study found nearly 78 percent of test subjects had neurofibrillary tangles in the substantia nigra. Annual neurological examinations included an assessment of parkinsonian signs using the Unified Parkinson's Disease Rating Scale. All 86 persons had at least some evidence of parkinsonian signs before death. Gait was the most severely affected domain followed by bradykinesia (slowness in movement), rigidity, and tremor. The study looked at the relationship between nigra tangles and each parkinsonian sign. It found that every 1,000 nigra tangles increased the gait score by more than three points. In contrast, nigra tangles were not related to bradykinesia, rigidity, or tremor. The relationship between substantia nigra tangles and gait impairment was found in persons with and without dementia. "This study shows that the spectrum of Alzheimer's disease is broader than we thought and may be more common than previously recognized. Alzheimer's disease doesn't just cause memory and cognitive problems, it is also causing motor problems in aging," says Schneider. "Gait problems in older people should not simply be passed over as a sign of aging. Physicians should be aware that this could be a possible early sign of Alzheimer's disease." Researchers at Rush continue to study if Alzheimer's disease pathology is impacting other motor regions of the brain and look into whether Alzheimer's disease can only affect motor function without causing cognitive or memory declines. Another study Schneider is currently conducting involves the relationship between dopamine, which is produced in the substantia nigra, and gait changes. More than 1000 older Catholic clergy from 40 groups across the U.S. are participating in the Religious Orders Study. The study is funded by the National Institute on Aging (NIA).All participants have agreed to annual memory testing and brain donation at the time of death. Schneider and her colleagues at the Rush Alzheimer's Disease Center are grateful for the remarkable dedication and altruism of this unique group of people committed to helping gain insights into how the brain functions with age. The Rush Alzheimer's Disease Center is one of 29 NIA-supported Alzheimer's Disease Centers across the U.S. which conduct basic science, clinical, and social and behavioral research on dementia and AD. General information on aging and aging research can be viewed at the NIA's home website, ©2004 Rush University Medical Center, Chicago, Illinois

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map