ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Fighting Heartburn and Gerd Naturally – And Safely!

 
Print Page
Email Article

Pathogenetic aspects of responsiveness to ondansetron 5-hydroxytryptamine type 3 receptor antagonist) in patients with primary fibromyalgia (FM) syndrome--a preliminary study

  [ 72 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 15, 1996


OBJECTIVE: To study the efficacy of 5-hydroxytryptamine type 3
receptor (5-HT-3R) antagonist (ondansetron) vs paracetamol in
primary fibromyalgia (FM) syndrome.

METHODS: A double blind,
crossover, latin square study of 21 patients with FM. Visual
analog scale (VAS) and body drawings were used to record pain
intensity. Functional symptoms were determined for using a
Likert-type self-developed protocol. Quantitative dolorimetry
was applied to assess the number of painful tender points and
the average pain threshold. Serum serotonin levels were
measured by a commercial ELISA.

RESULTS: A marked improvement
in pain intensity measured by VAS (p < 0.005), pain score (p
< 0.05), tender points (p < 0.05), and average pain threshold
(p < 0.01) was obtained with ondansetron, whereas no
improvement was seen with paracetamol. After ondansetron
treatment, there was also significant reduction in both
functional symptoms (p < 0.01) and headache intensity (p <
0.05). In patients who did not respond to ondansetron there
was higher baseline pain intensity measured by VAS (p < 0.05)
and pain score (p < 0.01), and a lower pain threshold (p <
0.05) compared to those who did respond well. In the
responsive group, no significant differences were seen in the
serotonin level before and after therapy. Whereas a
significant increase in serum serotonin concentration (p <
0.01) was observed in nonresponders after ondansetron
treatment.

CONCLUSION: Ondansetron appears to be an effective
drug in about 50% of patients with FM. There may be 2 subsets
of patients with FM that differ clinically and
pathogenetically with regard to the disturbance in the
5-HT-3R system.

Hrycaj P, Stratz T, Mennet P, Muller W




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Safely Burn Away Body Fat Safely Burn Away Body Fat
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map