ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Mint: Learn More About This Refreshing and Invigorating Herb

Give Your Health a Much-Needed Boost With Geranium

 
Print Page
Email Article

Pathogenetic aspects of responsiveness to ondansetron 5-hydroxytryptamine type 3 receptor antagonist) in patients with primary fibromyalgia (FM) syndrome--a preliminary study

  [ 72 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 15, 1996


OBJECTIVE: To study the efficacy of 5-hydroxytryptamine type 3
receptor (5-HT-3R) antagonist (ondansetron) vs paracetamol in
primary fibromyalgia (FM) syndrome.

METHODS: A double blind,
crossover, latin square study of 21 patients with FM. Visual
analog scale (VAS) and body drawings were used to record pain
intensity. Functional symptoms were determined for using a
Likert-type self-developed protocol. Quantitative dolorimetry
was applied to assess the number of painful tender points and
the average pain threshold. Serum serotonin levels were
measured by a commercial ELISA.

RESULTS: A marked improvement
in pain intensity measured by VAS (p < 0.005), pain score (p
< 0.05), tender points (p < 0.05), and average pain threshold
(p < 0.01) was obtained with ondansetron, whereas no
improvement was seen with paracetamol. After ondansetron
treatment, there was also significant reduction in both
functional symptoms (p < 0.01) and headache intensity (p <
0.05). In patients who did not respond to ondansetron there
was higher baseline pain intensity measured by VAS (p < 0.05)
and pain score (p < 0.01), and a lower pain threshold (p <
0.05) compared to those who did respond well. In the
responsive group, no significant differences were seen in the
serotonin level before and after therapy. Whereas a
significant increase in serum serotonin concentration (p <
0.01) was observed in nonresponders after ondansetron
treatment.

CONCLUSION: Ondansetron appears to be an effective
drug in about 50% of patients with FM. There may be 2 subsets
of patients with FM that differ clinically and
pathogenetically with regard to the disturbance in the
5-HT-3R system.

Hrycaj P, Stratz T, Mennet P, Muller W




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
How One Tiny Molecule Turned into One Huge Health Breakthrough How One Tiny Molecule Turned into One Huge Health Breakthrough
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Safely Burn Away Body Fat Safely Burn Away Body Fat

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map