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The relationship between fibromyalgia (FM) & major depressive disorder

  [ 52 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 20, 1996


Looking at the results of the seven types of studies discussed
previously, it appears that there is strong evidence for an
association between fibromyalgia and major depressive
disorder on the basis of (1) overlapping symptomatology, (2)
similar pattern of comorbid disorders, and (3) high rates of
major depressive disorder among relatives of patients with
fibromyalgia. There is additional support for an association
on the basis of responses to psychological tests and rating
scales and the high lifetime rates of mood disorders in
fibromyalgia. Two lines of evidence, (1) response to
antidepressant medications and (2) response to biologic
tests, offer little evidence either for or against an
association. On balance, then the weight of the evidence
favors an association between fibromyalgia and major
depressive disorder. We therefore turn to an analysis of the
nature of the association.

Hudson JI, Pope HG Jr




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