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Myasthenia-like syndrome induced by overdosage of cibenzoline

  [ 34 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 10, 1996


A case of cibenzoline-induced myasthenia-like syndrome is reported.
A 67-year-old woman with renal failure and no previous
disorder of neuromuscular junction complained of fatigue
during climbing up a flight of stairs and experiencing heavy
eyelids after administration of 100 mg/day of cibenzoline.
Repetitive nerve stimulation tests revealed decrement at 5-10
Hz. After reduction of the dosage, myasthenia-like signs and
symptoms disappeared. The peak cibenzoline concentration was
still high even after the dose reduction (666.4 ng/ml). In
conclusion, cibenzoline, at a high plasma level, may induce
myasthenia-like syndrome without any disorder of the
neuromuscular junction.

Kasuga A, Maruyama H, Sato T, Nogawa S, Mitamura H, Saruta T




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