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Possible correlation between Borna disease virus infection & Japanese patients with Chronic Fatigue Syndrome (CFS)

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www.ProHealth.com • January 15, 1996


Borna disease virus (BDV) is a neurotropic, as yet
unclassified, non-segmented, negative-sense, single-strand RNA
virus. Natural infection with this virus has been reported to
occur in horses and sheep. In addition, antibodies to BDV in
plasma or BDV RNA in peripheral blood mononuclear cells
(PBMCs) were also found in patients with neuropsychiatric
diseases. We describe here the possible link between the
patients with chronic fatigue syndrome (CFS) and infection
with BDV.

MCM: Studied 89 Japanese pts w CFS (1988 CDC) vs. 100 healthy
controls using ELISA with recombinant BDV p24 protein. Found
significantly higher (p<0.001) levels of BDV in CFS (also had
elevated late-antigen antibodies to HHV-6)...

Kitani T, Kuratsune H, Fuke I, Nakamura Y, Nakaya T, Asahi S,
Tobiume M, Yamaguti K, Machii T, Inagi R, Yamanishi K, Ikuta K




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