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Autoantibodies to nuclear envelope antigens in Chronic Fatigue Syndrome (CFS)

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www.ProHealth.com • October 15, 1996


We have identified and partially characterized the
autoantibodies in sera of 60 patients with chronic fatigue
syndrome. Approximately 52% of the sera were found to react
with nuclear envelope antigens. The combination of nuclear rim
staining observed in immunofluorescence microscopy and
immunoblot analysis of highly purified nuclear envelope
proteins provided initial characterization of these
autoantibodies. Further characterization showed that some
sera immunoprecipitated the in vitro transcription and
translation product of a human cDNA clone encoding the
nuclear envelope protein lamin B1. The autoantibodies were of
the IgG isotype. The occurrence of autoantibodies to a
conserved intracellular protein like lamin B1 provides new
laboratory evidence for an autoimmune component in chronic
fatigue syndrome.

MCM: Used 1988 CDC criteria. Control groups were (1) 10 w
Major depression, 10 with allergies, and 10 in good health, &
(2) 41 healthy blood donors. Of the CFS pts, 50% had psych
disorders, 50% FM, 28% positive Schirmer tests, and 58%
concurrent allergies. 68% were ANA positive, 52% had nuclear
rim staining, 47% had nucleoplasmic and nucleolar staining
(one colocalizing with p80 coilin) [to be separately
reported], and 33% had thread-like wavy cytoplasmic staining
in a vimentin-like pattern.

Konstantinov K, von Mikecz A, Buchwald D, Jones J, Gerace L, Tan EM




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