ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

CoQ10's Potential Capabilities for Your Health

Testosterone replacement therapy associated with improved urinary, sexual function

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

The Many Potential Health Benefits of Curcumin

8 Chia Seed Recipes

 
Print Page
Email Article

Sensory dysfunction in fibromyalgia (FM) patients with implications for pathogenic mechanisms

  [ 27 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 8, 1996


This study, addressing etiologic and pathogenic aspects of
fibromyalgia (FM), aimed at examining whether sensory
abnormalities in FM patients are generalized or confined to
areas with spontaneous pain. Ten female FM patients and 10
healthy, age-matched females participated. The patients were
asked to rate the intensity of ongoing pain using a visual
analogue scale (VAS) at the site of maximal pain, the
homologous contralateral site and two homologous sites with no
or minimal pain. Quantitative sensory testing was performed
for assessment of perception thresholds in these four sites.
Von Frey filaments were used to test low-threshold
mechanoreceptive function. Pressure pain sensitivity was
assessed with a pressure algometer and thermal sensitivity
with a Thermotest. In addition the stimulus-response curve of
pain intensity as a function of graded nociceptive heat
stimulation was studied at the site of maximal pain and at the
homologous contralateral site. FM patients had increased
sensitivity to non-painful warmth (P < 0.01) over painful
sites and a tendency to increased sensitivity to non-painful
cold (P < 0.06) at all sites compared to controls, but there
was no difference between groups regarding tactile perception
thresholds. Compared to controls, patients demonstrated
increased sensitivity to pressure pain (P < 0.001), cold pain
(P < 0.001) and heat pain (P < 0.02) over all tested sites.
The stimulus-response curve was parallely shifted to the left
of the curve obtained from controls (P < 0.003). Intragroup
comparisons showed that patients had increased sensitivity to
pressure pain (P < 0.01) and light touch (P < 0.05) in the
site of maximal pain compared to the homologous contralateral
site. These findings could be explained in terms of
sensitization of primary afferent pathways or as a dysfunction
of endogenous systems modulating afferent activity. However,
the generalized increase in sensitivity found in FM patients
was unrelated to spontaneous pain and thus most likely due to
a central nervous system (CNS) dysfunction. The additional
hyperphenomena related to spontaneous pain are probably
dependent on disinhibition/facilitation of nociceptive
afferent input from normal (or ischemic) muscles.

Kosek E, Ekholm J, Hansson P




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
How One Tiny Molecule Turned into One Huge Health Breakthrough How One Tiny Molecule Turned into One Huge Health Breakthrough

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map