ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Preliminary determination of the association between symptom expression & urinary metabolites in subjects with chronic fatigue syndrome

  [ 13 votes ]   [ Discuss This Article ] • June 10, 1996

Chronic fatigue syndrome (CFS) patients have a urinary metabolite
labeled CFSUM1 with increased incidence (P < 0.004) and
relative abundance (P < 0.00003). The relative abundances of
urinary CFSUM1 and beta-alanine were associated with
alterations in metabolite excretion and symptom incidence. In
20 CFS patients and 45 non-CFS subjects, symptom/metabolite
associations were investigated by assessing symptom
sensitivity and specificity, and symptom indices of total
symptom incidence, CFS core symptoms, cognitive,
neurological, musculoskeletal, gastrointestinal,
infection-related and genitourinary symptom indices, as well
as a visual analogue pain scale of average pain intensity.
Thirty-three symptoms had significant (P < 0.005) sensitivity
and specificity in the CFS patients compared to that in the
non-CFS controls. Severe fatigue was the only symptom with
100% sensitivity and specificity and CFSUM1 excretion was the
primary metabolite for expression of this symptom. All nine
symptom indices had elevated responses in the CFS patients
(all P < 0.0000001). Multiple regression analyses indicated
that all the symptom indices had significant correlations (R)
with changes in the urinary excretion of metabolites (P <
0.0001). CFSUM1 and beta-alanine were the first and second
metabolites correlated with the CFS core symptom index and
CFSUM1 was primarily associated with infection-related and
musculoskeletal indices whereas beta-alanine was primarily
associated with gastrointestinal and genitourinary indices.
The strong associations of CFSUM1 and beta-alanine with CFS
symptom expression provide a molecular basis for developing
an objective test for CFS.

McGregor NR, Dunstan RH, Zerbes M, Butt HL, Roberts TK, Klineberg IJ

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map