ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Fighting Heartburn and Gerd Naturally – And Safely!

Probiotics improve cognition in Alzheimer's patients

 
Print Page
Email Article

Fibromyalgia (FM) & migraine, 2 faces of the same mechanism. Serotonin as the common clue for pathogenesis & therapy

  [ 173 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 12, 1996


In this study fibromyalgia sufferers were randomly administered a
combination of monoamine-oxidase inhibitors (MAOIs)-A/B with
5-HTP, 5-HTP alone, MAOIs-A/B alone, or the tricyclic drug
amitriptyline in order to compare the efficacy of these
treatments. The benefits on the painful syndrome were assessed
by using Visual Analogic Scale score rating from 0 to 4. The
combination of MAOIs with 5-HTP significantly improved
fibromyalgia syndrome as determined by Visual Analogic Scale
whereas the other treatments yielded poorer benefits. No
subject withdrew from the trial due to adverse effects, even
if some sleep disturbances and mild stomach-ache were
reported. The tolerability of the association MAOIs/5-HTP was
good, although a transient cheese effect occurred in one of
the patients treated with MAOIs as well as in a patient
treated with the association MAOIs and 5-HTP. No one of these
two cases was due to pharmacological dietetic mistake of the
patient. In both the cases the transient hypertension was
associated to very dramatic emotional events. The benefits
obtained by using the combination of MAOIs with 5-HTP can be
explained with a treatment-induced enhancement of aminergic
and serotonergic transmission. The recently shown high
prevalence of migraine in the population of fibromyalgia
sufferers, suggests a common ground shared by fibromyalgia
and migraine. Migraine has been demonstrated to be
characterized by a defect in the serotonergic and adrenergic
systems. A parallel dramatic failure of serotonergic systems
and a defect of adrenergic transmission have been evidenced
to affect fibromyalgia sufferers too. Enhancing serotonergic
analgesia while increasing adrenergically mediated analgesia
seems to be an important tool in fibromyalgia. Treatment
consisting with the association MAOIs/5-HTP is aimed at
enhancing serotonergic/adrenergic transmission by inducing an
up-regulation of serotonergic/adrenergic receptors and a
simultaneous increase of serotonin levels in the central
nervous system.

Nicolodi M, Sicuteri F




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Ultra EPA  - Fish Oil Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map