ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Scientifically-designed fasting diet lowers risks for major diseases

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

A Little Zinc Goes a Long Way

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

Susceptibility to immunologically mediated fatigue in C57BL/6 versus Balb/c mice

  [ 43 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 5, 1996


Proinflammatory cytokines such as interleukin (IL)-1 and tumor
necrosis factor (TNF)-alpha have been proposed to play a role
in the pathogenesis of fatigue. In the present study we
compared the susceptibility of two mouse strains to
immunologically induced fatigue. Daily running of two strains
of mice, Balb/c and C57BL/ 6, was assessed after a single
injection of Corynebacterium parvum antigen (2 mg/mouse).
Spontaneous running activity of each animal was compared to
mean running distance prior to injection. To evaluate the
involvement of cytokines in fatigue development, C57BL/6 mice
were treated with antibodies to specific cytokines at the
time of challenge with C. parvum antigen. Also, cytokine mRNA
expression was analyzed in the brains of mice at different
time periods after immunologic challenge.

A significant
difference in running activity between the two mice strains
was observed after C. parvum antigen inoculation: C57BL/6
mice showing a greater (P < 0.05) reduction in running
activity (relative to preinjection levels) and slower
recovery to baseline than Balb/c mice. Injection of
antibodies specific to either IL-1beta or TNF-alpha did not
alter immunologically induced fatigue, suggesting a lack of
involvement of these cytokines produced outside of the
central nervous system (CNS). However, increased TNF-alpha
and IL-1beta mRNA expression was found in the brains of
C57BL/6 compared to that seen in Balb/c mice at 6, 10, and 15
days after C. parvum antigen injection. The elevated CNS
cytokine mRNA expression corresponded to development of
fatigue. These findings are consistent with the hypothesis
that expression of proinflammatory cytokines within the CNS
plays a role in the pathogenesis of immunologically mediated
fatigue.

Sheng WS, Hu S, Lamkin A, Peterson PK, Chao CC




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map