ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Trimming the spare tire: Canola oil may cut belly fat

 
Print Page
Email Article

Sensory characterization of somatic parietal tissues in humans with Chronic Fatigue Syndrome (CFS)

  [ 72 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 19, 1996


Patients with chronic fatigue syndrome (CFS) mainly complain
of symptoms in the musculoskeletal domain (myalgias, fatigue).

In 21 CFS patients the deep (muscle) versus superficial
(skin, subcutis) sensitivity to pain was explored by
measuring pain thresholds to electrical stimulation
unilaterally in the deltoid, trapezius and quadriceps and
overlying skin and subcutis in comparison with normal
subjects. Thresholds in patients were normal in skin and
subcutis but significantly lower than normal(hyperalgesia)
in muscles (P < 0.001) in all sites. The selective muscle
hypersensitivity corresponded also to fiber abnormalities at
musclebiopsy (quadriceps) performed in nine patients which
were absent in normal subjects (four cases): morphostructural
alterations of the sarchomere, fatty degeneration and fibrous
regeneration, inversion of the cytochrome oxidase/succinate
dehydrogenase ratio, pleio/polymorphism andmonstruosity of
mitochondria, reduction of some mitochondrial enzymatic
activities and increments of common deletion of 4977 bp of
mitochondrial DNA 150-3000 times the normal values. By
showing both sensory (diffuse hyperalgesia) and anatomical
(degenerative picture) changes at muscle level, the results
suggest a role played by peripberal mechanisms in the genesis
of CFS symptoms. They would exclude the heightened perception
of physiological signals from all districts hypothesized by
some authors,especially as the hyperalgesia is absent in
skin/subcutis.

Vecchiet L, Montanari G, Pizzigallo E, Iezzi S, de Bigontina P,
Dragani L, Vecchiet J, Giamberardino MA




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map