ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Sensory characterization of somatic parietal tissues in humans with Chronic Fatigue Syndrome (CFS)

  [ 72 votes ]   [ Discuss This Article ] • April 19, 1996

Patients with chronic fatigue syndrome (CFS) mainly complain
of symptoms in the musculoskeletal domain (myalgias, fatigue).

In 21 CFS patients the deep (muscle) versus superficial
(skin, subcutis) sensitivity to pain was explored by
measuring pain thresholds to electrical stimulation
unilaterally in the deltoid, trapezius and quadriceps and
overlying skin and subcutis in comparison with normal
subjects. Thresholds in patients were normal in skin and
subcutis but significantly lower than normal(hyperalgesia)
in muscles (P < 0.001) in all sites. The selective muscle
hypersensitivity corresponded also to fiber abnormalities at
musclebiopsy (quadriceps) performed in nine patients which
were absent in normal subjects (four cases): morphostructural
alterations of the sarchomere, fatty degeneration and fibrous
regeneration, inversion of the cytochrome oxidase/succinate
dehydrogenase ratio, pleio/polymorphism andmonstruosity of
mitochondria, reduction of some mitochondrial enzymatic
activities and increments of common deletion of 4977 bp of
mitochondrial DNA 150-3000 times the normal values. By
showing both sensory (diffuse hyperalgesia) and anatomical
(degenerative picture) changes at muscle level, the results
suggest a role played by peripberal mechanisms in the genesis
of CFS symptoms. They would exclude the heightened perception
of physiological signals from all districts hypothesized by
some authors,especially as the hyperalgesia is absent in

Vecchiet L, Montanari G, Pizzigallo E, Iezzi S, de Bigontina P,
Dragani L, Vecchiet J, Giamberardino MA

Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Optimized Curcumin Longvida® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map