ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Antioxidant treatment could halt neurodegeneration in early Parkinson's

Higher vitamin D levels associated with less severe disease in NAFLD patients

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

Everything You Need to Know About Black Cohosh

 
Print Page
Email Article

Randomised, double-blind, placebo-controlled study of fluoxetine in Chronic Fatigue Syndrome (CFS)

  [ 34 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 30, 1996


BACKGROUND: No somatic treatment has been found to be
effective for chronic fatigue syndrome (CFS). Antidepressant
therapy is commonly used. Fluoxetine is recommended in
preference to tricyclic agents because it has fewer sedative
and autonomic nervous system effects. However, there have been
no randomised, placebo-controlled, double-blind studies
showing the effectiveness of antidepressant therapy in CFS. We
have carried out such a study to assess the effect of
fluoxetine in depressed and non-depressed CFS patients.

METHODS: In this randomised, double-blind study, we recruited
44 patients to the depressed CFS group, and 52 to the
non-depressed CFS group. In each group participants were
randomly assigned to receive either fluoxetine (20 mg once
daily) or placebo for 8 weeks. The effect of fluoxetine was
assessed by questionnaires, self-observation lists, standard
neuropsychological tests, and a motion-sensing device
(Actometer), which were applied on the day treatment started
and on the last day.

FINDINGS: The two groups were well
matched in terms of age, sex distribution, employment and
marital status, and duration of CFS. There were no significant
differences between the placebo and fluoxetine-treated groups
in the change during the 8-week treatment period for any
dimension of CFS. There was no change in subjective
assessments of fatigue, severity of depression, functional
impairment, sleep disturbances, neuropsychological function,
cognitions, or physical activity in the depressed or the
non-depressed subgroup.

INTERPRETATION: Fluoxetine in a 20 mg
daily dose does not have a beneficial effect on any
characteristic of CFS. The lack of effect of fluoxetine on
depressive symptoms in CFS suggests that processes underlying
the presentation of depressive symptoms in CFS may differ from
those in patients with major depressive disorder.

MCM: 20 mg/day does not have a beneficial effect on any
characteristic of CFS."The lack of effect of fluoxetine on
depressive symptoms in CFS suggets that processes underlying
the presentation of depressive symptoms in CFS may differ from
those in pts w major depressive disorder.

Vercoulen JH, Swanink CM, Zitman FG, Vreden SG, Hoofs MP, Fennis JF,
Galama JM,van der Meer JW, Bleijenberg G




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map