ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

AMA journal associates iron deficiency with hearing loss

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Lutein linked to preservation of crystallized intelligence

 
Print Page
Email Article

Salmonella's molecular mimics may spark arthritis

  [ 5 votes ]   [ Discuss This Article ]
By Wei-Feng Lo, M.D., Ph.D., Amy DeCloux, Ph.D., Amina S. Woods, Ph.D., and Robert J. Cotter, Ph.D., of Johns Hopkins, as well as Eleanor S. Metcalf, Ph.D., of the Uniformed Services University of the Health Sciences in Bethesda, Md. • www.ProHealth.com • April 12, 2000


SUMMARY: Scientists at Johns Hopkins have uncovered an important link between getting specific bacterial infections and developing autoimmune diseases such as arthritis. In one study researchers show clearly that immune system cells which fight bacteria can also attack normal cells carrying a specific mimic molecule -- one that closely resembles a bacterial protein. Researchers found as many as 10 percent of those who get Salmonella develop a reactive kind of arthritis which lasts a few weeks and a smaller portion develop a severe, debilitating type of arthritis that's long-lasting.

ABSTRACT: Scientists at Johns Hopkins have uncovered an important link between getting specific bacterial infections and developing autoimmune diseases such as arthritis.
In a study reported in this month's edition of the journal Nature Medicine, the researchers show clearly that immune system cells which fight bacteria can also attack normal cells carrying a specific mimic molecule -- one that closely resembles a bacterial protein.
Further, they show that as long as there's been a previous bacterial infection, immune cells can attack "innocent bystander" cells -- body cells that bacteria have never infected. This occurs when the cells are stressed by exposure to irradiation, environmental toxins or the body's stress chemicals.
"We've found this evidence that the immune system can be fooled," says Mark Soloski, Ph.D, who led the research team, "and it suggests subtle changes that could underlie many autoimmune diseases." The study also offers a starting place for scientists to investigate environmental or genetic triggers to autoimmune diseases.
The team focused on infections by Salmonella, bacteria well known for food poisoning but also long thought to trigger arthritis in some people. "As many as 10 percent of those who get Salmonella develop a reactive kind of arthritis which lasts a few weeks," says Soloski. "But a smaller, significant number of those patients get a severe, debilitating type of arthritis that's long-lasting."
To investigate bacteria/arthritis connections, the scientists observed behavior of a typical bacteria-fighting immune cell, the cytotoxic lymphocyte (CTL), as it approached infected body cells. Cells invaded by bacteria normally give clear signals that they're infected. "They display small pieces of bacterial proteins on their surface that say, in effect, 'Hey, here's a sick cell,'" says Soloski. Attracted by this protein "flag," CTLs dock with the infected cells and trigger their rapid self-destruction.
The Hopkins scientists first identified the protein "flag" in mouse cells infected with Salmonella as one common to certain bacteria associated with human arthritis, including Borrelia -- the cause of Lyme disease.
But they also found the bacterial "flag" was almost identical to parts of a "universal housekeeping molecule" found in humans, mice and all living organisms. This "housekeeping molecule" helps proteins keep their shape.
When researchers artificially coaxed mouse body cells to display the Salmonella "flag," the mouse CTLs would readily attack them. But CTLs also went into attack mode if the cells displayed a piece of the mouse's own housekeeping molecule or the identical human version. "This shows us the immune cells readily respond to a molecular mimic," says Soloski.
In a normal Salmonella infection in mice, Soloski says "at least half of the CTLs are stirred up to recognize the mouse's own protein as well as the bacterial one. That's a huge immune response." Based on the similarity of the set-up in humans, he adds, the response is likely the same. Now the scientists are trying to find why and how this immune response translates into arthritis in some mice and humans.
In a small side study, the team also found that normal, uninfected body cells could be attacked by CTLs if the cells were stressed in some way, such as being exposed to higher temperature or radiation or general infection. "We don't know what's going on here," says Soloski, "but it's a good place to study other triggers of autoimmune diseases."
The research was funded by NIH grants and by an award from the Maryland Chapter of The Arthritis Foundation.
Source: Johns Hopkins Medical Institutions



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map