ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Print Page
Email Article

Contrasting neuroendocrine responses in depression & Chronic Fatigue Syndrome (CFS)

  [ 26 votes ]   [ Discuss This Article ] • August 18, 1995

Hypothalamic-pituitary-adrenal (HPA) axis and central 5-HT function
were compared in chronic fatigue syndrome (CFS), depression
and healthy states. 10 patients with CFS and 15 patients with
major depression were matched for age, weight, sex and
menstrual cycle with 25 healthy controls.

Baseline-circulating cortisol levels were highest in the depressed, lowest in
the CFS and intermediate between the two in the control group (P =
0.01). Prolactin responses to the selective 5-HT-releasing
agent d-fenfluramine were lowest in the depressed, highest in
the CFS and intermediate between both in the healthy group (P
= 0.01). Matched pair analysis confirmed higher prolactin
responses in CFS patients than controls (P = 0.05) and lower
responses in depressed patients than controls (P = 0.003).
There were strong inverse correlations between prolactin and
cortisol responses and baseline cortisol values. These data
confirm that depression is associated with hypercotisolaemia
and reduced central 5-HT neurotransmission and suggest that
CFS may be associated with hypocortisolaemia and increased
5-HT function. The opposing responses in CFS and depression
may be related to reversed patterns of behavioural dysfunction
seen in these conditions. These findings attest to biological
distinctions between these disorders.

MCM: Studied 10 nondepressed CDC-criteria CFS patients, 15
with major depression (MD), and 25 healthy controls.Measured
baseline blood cortisol and prolactin and hourly levels to 5
hours after injection with the 5-hydroxytryptamine (serotonin)
agonist d-Fenfluramine.Prolactins at baseline did not differ
significantly but CFS pts rose to significantly greater levels
compared to normals whereas MD pts rose to significantly
lesser levels than normals.Cortisols at baseline were
significantly lower inCFS pts and significantly higher in
MD.After the injection, cortisol levels in CFS remained
significantly lower compared to normals whereas in MD pts,
cortisol levels remained significantly higher compared to
normals."The opposing responses in CFS and depression may be
related to reversed patterns of behavioral dysfunction seen in
these conditions.These findings attest to biological
differences between these disorders."

Cleare AJ, Bearn J, Allain T, McGregor A, Wessely S, Murray RM,
O'Keane V

Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength FibroSleep™ Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map