ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

Why the Mediterranean Diet Is so Successful

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

Wearable biosensors can flag illness, Lyme disease, risk for diabetes; low airplane oxygen

VIDEO: The Best Brain Foods That Help Increase Your Memory!

More evidence for calorie restriction’s longevity effect

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

 
Print Page
Email Article

Contrasting neuroendocrine responses in depression & Chronic Fatigue Syndrome (CFS)

  [ 26 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 18, 1995


Hypothalamic-pituitary-adrenal (HPA) axis and central 5-HT function
were compared in chronic fatigue syndrome (CFS), depression
and healthy states. 10 patients with CFS and 15 patients with
major depression were matched for age, weight, sex and
menstrual cycle with 25 healthy controls.

Baseline-circulating cortisol levels were highest in the depressed, lowest in
the CFS and intermediate between the two in the control group (P =
0.01). Prolactin responses to the selective 5-HT-releasing
agent d-fenfluramine were lowest in the depressed, highest in
the CFS and intermediate between both in the healthy group (P
= 0.01). Matched pair analysis confirmed higher prolactin
responses in CFS patients than controls (P = 0.05) and lower
responses in depressed patients than controls (P = 0.003).
There were strong inverse correlations between prolactin and
cortisol responses and baseline cortisol values. These data
confirm that depression is associated with hypercotisolaemia
and reduced central 5-HT neurotransmission and suggest that
CFS may be associated with hypocortisolaemia and increased
5-HT function. The opposing responses in CFS and depression
may be related to reversed patterns of behavioural dysfunction
seen in these conditions. These findings attest to biological
distinctions between these disorders.

MCM: Studied 10 nondepressed CDC-criteria CFS patients, 15
with major depression (MD), and 25 healthy controls.Measured
baseline blood cortisol and prolactin and hourly levels to 5
hours after injection with the 5-hydroxytryptamine (serotonin)
agonist d-Fenfluramine.Prolactins at baseline did not differ
significantly but CFS pts rose to significantly greater levels
compared to normals whereas MD pts rose to significantly
lesser levels than normals.Cortisols at baseline were
significantly lower inCFS pts and significantly higher in
MD.After the injection, cortisol levels in CFS remained
significantly lower compared to normals whereas in MD pts,
cortisol levels remained significantly higher compared to
normals."The opposing responses in CFS and depression may be
related to reversed patterns of behavioral dysfunction seen in
these conditions.These findings attest to biological
differences between these disorders."

Cleare AJ, Bearn J, Allain T, McGregor A, Wessely S, Murray RM,
O'Keane V




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map