ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Cassia Bark Oil: Why It's Valuable in Traditional Chinese Medicine

Hormone replacement therapy associated with lower risk of dying over eight year follow-up period

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

 
Print Page
Email Article

Contrasting neuroendocrine responses in depression & Chronic Fatigue Syndrome (CFS)

  [ 26 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 18, 1995


Hypothalamic-pituitary-adrenal (HPA) axis and central 5-HT function
were compared in chronic fatigue syndrome (CFS), depression
and healthy states. 10 patients with CFS and 15 patients with
major depression were matched for age, weight, sex and
menstrual cycle with 25 healthy controls.

Baseline-circulating cortisol levels were highest in the depressed, lowest in
the CFS and intermediate between the two in the control group (P =
0.01). Prolactin responses to the selective 5-HT-releasing
agent d-fenfluramine were lowest in the depressed, highest in
the CFS and intermediate between both in the healthy group (P
= 0.01). Matched pair analysis confirmed higher prolactin
responses in CFS patients than controls (P = 0.05) and lower
responses in depressed patients than controls (P = 0.003).
There were strong inverse correlations between prolactin and
cortisol responses and baseline cortisol values. These data
confirm that depression is associated with hypercotisolaemia
and reduced central 5-HT neurotransmission and suggest that
CFS may be associated with hypocortisolaemia and increased
5-HT function. The opposing responses in CFS and depression
may be related to reversed patterns of behavioural dysfunction
seen in these conditions. These findings attest to biological
distinctions between these disorders.

MCM: Studied 10 nondepressed CDC-criteria CFS patients, 15
with major depression (MD), and 25 healthy controls.Measured
baseline blood cortisol and prolactin and hourly levels to 5
hours after injection with the 5-hydroxytryptamine (serotonin)
agonist d-Fenfluramine.Prolactins at baseline did not differ
significantly but CFS pts rose to significantly greater levels
compared to normals whereas MD pts rose to significantly
lesser levels than normals.Cortisols at baseline were
significantly lower inCFS pts and significantly higher in
MD.After the injection, cortisol levels in CFS remained
significantly lower compared to normals whereas in MD pts,
cortisol levels remained significantly higher compared to
normals."The opposing responses in CFS and depression may be
related to reversed patterns of behavioral dysfunction seen in
these conditions.These findings attest to biological
differences between these disorders."

Cleare AJ, Bearn J, Allain T, McGregor A, Wessely S, Murray RM,
O'Keane V




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Ultra EPA  - Fish Oil Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
"It's Not Easy Being Green" - But It Is Healthy
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map