ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Meta-analysis adds evidence to association between omega-3 supplementation and lower heart rate

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

Essential Oils Lower Blood Pressure

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Print Page
Email Article

Fat May Affect Electrical Impulses in Brain, Heart

  [ 99 votes ]   [ Discuss This Article ] • April 15, 2005

Source: Washington University School of Medicine Molecules attach to proteins that regulate bioelectricity April 14, 2005 -

- Fatty molecules may modulate the electrical characteristics of nerve and heart cells by regulating the properties of key cell pores, according to research conducted at Washington University School of Medicine in St. Louis. The findings suggest a novel mechanism in which dietary fat can attach directly to proteins that regulate bioelectricity. This can affect the performance of nerve and heart cells, with potentially broad-ranging health implications. The researchers report in the April 26 issue of the Proceedings of the National Academy of Sciences that the proteins in specific electrically responsive cell pores--voltage-sensing potassium channels--can bind to molecules of palmitate.

Palmitate is a saturated fatty acid previously linked to "hardening" of the arteries and obesity and is a common fat in unhealthy diets. "In effect, the attachment of palmitate makes these potassium channels, called Kv1.1 channels, open more easily, and this can influence the transmission of electrical impulses along nerve cells and the contraction of heart muscle cells," says senior author Richard Gross, M.D., Ph.D., professor of medicine, of chemistry and of molecular biology and pharmacology and director of the Division of Bioorganic Chemistry and Molecular Pharmacology.

Potassium channels are among the most important cell channels used for propagating electrical signals in nerve and heart muscle. Their protein units form pores that permeate the outer wall or membrane of the cell and selectively allow the passage of potassium ions, which are essential components of cell signaling systems. Like a meter that measures charge in a battery, a Kv1.1 channel senses the amount of voltage between the interior and exterior of cells and can open and close in response to voltage changes. Because they are embedded in the cell membrane, Kv1.1 channels are tightly surrounded by the fatty molecules of the membrane, which line up next to each other to create a stable structure. "We think the attached palmitate molecule causes a defect in the close, regular packing of the membrane's fatty molecules around the Kv1.1 channel, because the palmitate has a different shape," Gross says. "This shape loosens the membrane packing, changes the movement of the channel protein and alters the voltage needed for it to open or close."

The researchers identified the specific site or amino acid in the Kv1.1 protein units that palmitate most often links to. They discovered that a short sequence of amino acids on either side of the attachment site is found in several other proteins as well, arguing for an evolutionarily conserved function for this amino acid sequence. Most strikingly, five of six amino acids adjacent to the attachment site matched a site where palmitate is known to attach to CD36, an abundant protein vital for moving fatty molecules through the membrane into cells. "When we see that molecules as widespread, as important and as different from each other as CD36 and Kv1.1 are linked to palmitate at the same sequence--that's nature sending us a message," Gross says. "It's possible that this palmitate attachment site has been used throughout evolution to fulfill functions involving fatty molecules."

Future investigations will seek to further characterize the electrical properties conferred by the addition of palmitate to Kv1.1. The research team will also begin studies with mice to determine the effects of dietary fats on palmitate attachment and the electrical characteristics of cells. "We want to find out if a connection exists between dietary fats, the attachment of palmitate to proteins and health," Gross says. "In obesity or in cellular lipotoxicity, you exceed cells' capacity to handle fatty acids. Accumulation of fatty acids can lead to an increase in alterations like palmitate attachment, not only in Kv1.1, but in dozens or even hundreds of other proteins. That possibly explains some of the many types of damage that result from having too high of a fatty acid burden."

Gubitosi-Klug RA, Mancuso DJ, Gross RW. The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence. Proceedings of the National Academy of Sciences. 2005;102(17): 5964-5968.

Funding from the National Institutes of Health supported this research. Washington University School of Medicine's full-time and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked third in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Energy NADH™ 12.5mg

Article Comments

Be the first to comment on this article!

Post a Comment

Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Live Without Anxiety or Stress Live Without Anxiety or Stress
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More
Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
The Genetic Mutation That May Compromise Your Health - And What to Do About It The Genetic Mutation That May Compromise Your Health - And What to Do About It

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map