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SAMe (S-adenosylmethionine): The Link Between Homocysteine & Depression

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By Source; Health Watch • • February 1, 1999

Each year thousands of people suffer from serious bouts of depression, which is the leading cause of suicide. According to the National Center for Health Statistics (NCHS), every American will suffer at least one bout of depression during their lifetime. People with serious physical illness are often depressed, and it is occurring with greater frequency in the elderly and in young adults. While pharmaceutical antidepressants work in most patients, there are often significant drawbacks. Troublesome side effects include nausea, headaches, anxiety and nervousness, insomnia, drowsiness, diarrhea, dry mouth, sweating, and tremors. A natural remedy, however, does exist. S-adenosylmethionine (SAM) is a bioactive form of the amino acid methionine created naturally in the body and may be the most powerful natural antidepressant available.

In the 1970's, while testing SAMe as a treatment for schizophrenia, Italian researchers discovered that the depression levels in their patients had greatly decreased. This set off a wave of research that has accelerated recently. According to the Neuroscience Behavioral Review, in study after study, SAMe is equal, or superior, to frequently prescribed pharmaceutical agents in overcoming depression. It has been proven effective in handling every type of depression, especially the endogenous form where people are depressed without any apparent external cause, in cases such as CFIDS and fibromyalgia where depression is frequent. Not only may it be more effective, but SAMe also works faster and without any negative side effects.

As research on SAMe continues, numerous other uses for this naturally occurring compound are being discovered and tested. Besides serving as an effective antidepressant, SAMe has proven by Di Benedetto and her colleagues at the Rehabilitation Center in Trieste, Italy to be a valuable therapy for several other conditions, including liver cirrhosis, osteoarthritis, and fibromyalgia. In a study by the Scandinavian Journal of Rheumatology, 800 mg of SAMe per day for six weeks significantly improved "clinical disease activity", pain, and morning stiffness in patients with fibromyalgia. Chronic fatigue patients were not involved in this study.

Although the synthesized SAMe is expensive, your body can produce SAMe naturally by utilizing the four specific nutritional supplements. The same combination of vitamin B6, folic acid, vitamin B12, and Trimethylglycine (TMG) that actively combat high homocysteine levels also allow the body to produce SAM naturally.

In this dual reaction, the TMG is turned into dimethylglycine (DMG) while the B6, Folic Acid, and B12 convert the homocysteine into beneficial amino acid products. This lowers homocysteine levels while simultaneously producing SAMe. The natural production of DMG, one of the most popular and expensive energy and vitality enhancing nutritional supplements on the market, is yet another benefit to this supplemental combination. Not only does this combination of TMG, B6, Folic Acid, and B12 greatly improve your health and well being, they also save you money. These nutrients produce SAMe and DMG naturally at a fraction of the cost of the commercially available pharmaceutical substitutes.

For a limited time order online and take $3.00 of SAMe!

SAM-e Online Price Comparison

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