ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Ylang Ylang Oil Not Only Soothes Your Skin, but Your Mind as Well

Exercises to Help Prevent Urinary Incontinence

 
Print Page
Email Article

Chronic active Epstein-Barr virus disease in a case of persistent polyclonal B-cell lymphocytosis

  [ 28 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 5, 1995


Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare
haematological disorder. It is characterized by activated and
morphologically atypical B lymphocytes and polyclonal IgM
production and has been associated with female sex, cigarette
smoking, and HLA-DR7 expression. We report a case of PPBL with
intermitting symptoms compatible with a chronic fatigue
syndrome, recurrent erythema nodosum and multiforme.
Serological findings suggested a chronic active Epstein-Barr
virus (EBV) infection. Messenger RNA of EBV immediate early
gene transactivation BZLF1 was detected in peripheral blood
lymphocytes by reverse transcriptase PCR indicating a
persistent replication of the virus. Over 2 years of
observation we detected varying numbers of atypical
lymphocytes. These cells hybridized with a probe specific for
the EBV internal repeat region (BamHI W) which indicates a
productive infection. Of interest, no reaction was observed
with a probe specific for the latency-associated small RNAs
(EBERs). The immunological phenotype of the polyclonal B cells
was similar to B-cell lines immortalized by EBV in vitro,
expressing a number of activation molecules (CD23, CD25, CD54)
and the bcl-2 protein. In summary, our findings suggest that
persistent EBV replication might be crucial in the development
of lymphoproliferative disorders such as PPBL.

Mitterer M, Pescosta N, Fend F, Larcher C, Prang N, Schwarzmann F,
Coser P, Huemer HP




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Vitamin D3 Extreme™ FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map