ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

CoQ10's Potential Capabilities for Your Health

How Can Melatonin Benefit You?

Testosterone replacement therapy associated with improved urinary, sexual function

Cloves: Boost Your Immune System the Sweet and Spicy Way

8 Chia Seed Recipes

The Many Potential Health Benefits of Curcumin

 
Print Page
Email Article

The disease associations of the antibody response against the EB virus transactivator protein ZEBRA can be separated into different epitopes

  [ 28 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 2, 1995


The BamHI-Z-encoded Epstein-Barr virus (EBV) replication activator
(ZEBRA) is a key mediator of the switch from latency to
productive cycle in EBV virus. Antibodies against ZEBRA are a
marker of EBV reactivation and are regularly found among
patients with infectious mononucleosis (IM) or nasopharyngeal
carcinoma (NPC), but are only rarely found among healthy
EBV-seropositive donors. In order to define the serologically
reactive epitopes in the ZEBRA protein, we synthesized a set
of overlapping peptides and tested them for reactivity with
serum samples from EBV-seronegative persons, patients with
NPC, IM, chronic fatigue syndrome, lymphoma or from healthy
donors.

Three major EBV-specific epitopes were found. These
epitopes were further defined and optimized using substitution
or truncation analogues of the peptides. Reactivity with
epitope number 22 was found in 63% of NPC patients' sera, with
< 2% of healthy donors' sera being positive. Serological
reactivity with epitope number 19 was associated with IM (57%
positive, 5% healthy donors positive). Serum antibodies
against epitope 1 were found among healthy donors, but were
significantly elevated among patients with NPC, IM or
lymphomas. In conclusion, different serologically reactive
epitopes in the ZEBRA protein associate with different
EBV-associated diseases.

Tedeschi R, Foong YT, Cheng HM, dePaoli P, Lehtinen T, Elfborg T,
Dillner J




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map