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The validity & reliability of the fatigue syndrome that follows glandular fever

  [ 26 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 5, 1995


The validity and reliability of an empirically defined fatigue
syndrome were tested in a prospective cohort study of 245
primary care patients, with glandular fever or an upper
respiratory tract infection. Subjects were interviewed three
times in the 6 months after onset. Subjects with the
empirically defined fatigue syndrome were compared with those
who were well and those who had a psychiatric disorder. The
validity of the fatigue syndrome was supported, separate from
psychiatric disorders in general and depressive disorders in
particular. Only 16% of subjects with the principal component
derived fatigue factor also met criteria for a psychiatric
disorder (excluding pre-morbid phobias). Compared with
subjects with psychiatric disorders, subjects with the
operationally defined fatigue syndrome reported more severe
physical fatigue, especially after exertion, were just as
socially incapacitated, had fewer mental state abnormalities,
and showed little overlap on independent questionnaires. A
more mild fatigue state also existed. Both fatigue syndrome
and state were more reliable diagnoses over time than
depressive disorders. The empirically defined syndrome
probably is a valid and reliable condition in the six months
following glandular fever.

White PD, Grover SA, Kangro HO, Thomas JM, Amess J, Clare AW




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