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Borrelia burgdorferi reactivity in patients with severe persist fatigue who are from a region .. Lyme disease is endemic

  [ 1 vote ]   [ Discuss This Article ]
www.ProHealth.com • January 3, 1994


Borrelia burgdorferi is the pathogen that causes Lyme disease.
Patients frequently experience fatigue and malaise that can
persist after antibiotic treatment. This study examined
serological reactivity to B. burgdorferi in patients with
chronic fatigue who were from a region in which Lyme disease
is endemic. Blood and CSF were collected from patients without
a history of infection due to B. burgdorferi (n = 12) and
patients with persistent fatigue after antibiotic treatment of
Lyme disease (n = 13). Serum and CSF were examined by ELISA
for antibodies to B. burgdorferi, and routine studies of CSF
were done. In the first group, one patient (8%) was
seropositive; no patients had detectable antibodies in CSF. In
the second group, nine patients (69%) were seropositive or
borderline seropositive; seven (54%) had detectable antibodies
in CSF. Unexplained abnormalities in CSF were noted in 42% and
31% of patients in each group, respectively. In this study
positive serologies for Lyme disease were not found at a
higher than expected rate for patients from a region of Lyme
disease endemicity who had idiopathic chronic fatigue.
Fatigued patients did show a surprisingly high rate of
unexplained minor CSF abnormalities suggestive of CNS or
meningeal dysfunction.

Coyle PK, Krupp LB, Doscher C, Amin K




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