ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Curcumin Reverses the Cellular Damage of Chronic Stress

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

 
Print Page
Email Article

Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia (FM)

  [ 67 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 2, 1994


OBJECTIVE. To examine basal and stimulated
hypothalamic-pituitary-adrenal (HPA) axis and related hormone
levels, including adrenocorticotropin (ACTH), cortisol,
arginine vasopressin (AVP), and neuropeptide Y (NPY), in
patients with fibromyalgia (FM).

METHODS. Basal and ovine
corticotropin-releasing hormone (oCRH)-stimulated HPA axis
function were assessed in 12 patients with FM and in age- and
sex-matched normal subjects. Basal plasma AVP levels and AVP
release after postural change were assessed, and plasma NPY
levels ["colocalizes w norepinephrine and stimulated
peripherally during stress"] were measured in the same
samples.

RESULTS. Patients with FM had low 24-hour urinary
free cortisol, but normal peak [i.e., at 0800] and elevated
trough [i.e, at2000] plasma cortisol levels, compared with
normal subjects. The net integrated ACTH response to oCRH in
FM was not significantly different from that in normal
subjects, but tended toward an exaggerated response. There was
a significant decrease in net integrated cortisol response to
oCRH in FM patients, indicating adrenal hyporesponsiveness.
AVP levels were not significantly different between FM
patients and control subjects, but variability was greater
among the FM patients. Plasma NPY levels were significantly
lower in FM patients than in normal subjects.

CONCLUSION. These data support the view that HPA axis
function is perturbed in patients with FM. Further study is
required to ascertain the cause of HPA axis perturbations and
their relationship to symptoms in patients with FM.

Crofford LJ, Pillemer SR, Kalogeras KT, Cash JM, Michelson D, Kling
MA, Sternberg EM, Gold PW, Chrousos GP, Wilder RL




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map