ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Meta-analysis adds evidence to association between omega-3 supplementation and lower heart rate

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

Essential Oils Lower Blood Pressure

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

 
Print Page
Email Article

Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia (FM)

  [ 67 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 2, 1994


OBJECTIVE. To examine basal and stimulated
hypothalamic-pituitary-adrenal (HPA) axis and related hormone
levels, including adrenocorticotropin (ACTH), cortisol,
arginine vasopressin (AVP), and neuropeptide Y (NPY), in
patients with fibromyalgia (FM).

METHODS. Basal and ovine
corticotropin-releasing hormone (oCRH)-stimulated HPA axis
function were assessed in 12 patients with FM and in age- and
sex-matched normal subjects. Basal plasma AVP levels and AVP
release after postural change were assessed, and plasma NPY
levels ["colocalizes w norepinephrine and stimulated
peripherally during stress"] were measured in the same
samples.

RESULTS. Patients with FM had low 24-hour urinary
free cortisol, but normal peak [i.e., at 0800] and elevated
trough [i.e, at2000] plasma cortisol levels, compared with
normal subjects. The net integrated ACTH response to oCRH in
FM was not significantly different from that in normal
subjects, but tended toward an exaggerated response. There was
a significant decrease in net integrated cortisol response to
oCRH in FM patients, indicating adrenal hyporesponsiveness.
AVP levels were not significantly different between FM
patients and control subjects, but variability was greater
among the FM patients. Plasma NPY levels were significantly
lower in FM patients than in normal subjects.

CONCLUSION. These data support the view that HPA axis
function is perturbed in patients with FM. Further study is
required to ascertain the cause of HPA axis perturbations and
their relationship to symptoms in patients with FM.

Crofford LJ, Pillemer SR, Kalogeras KT, Cash JM, Michelson D, Kling
MA, Sternberg EM, Gold PW, Chrousos GP, Wilder RL




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength FibroSleep™ Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium

Natural Remedies

Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map