ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

On-and-off fasting helps fight obesity, study finds

Can Pomegranates Slow Aging?

Calorie restriction promotes longevity through effects on mitochondrial network

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

How Can You Benefit From Vitamin B12?

A spoonful of oil: Fats and oils help to unlock full nutritional benefits of veggies, study suggests

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

What Is Bitter Orange?

Drug can dramatically reduce weight of people with obesity

 
Print Page
Email Article

Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia (FM)

  [ 67 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 2, 1994


OBJECTIVE. To examine basal and stimulated
hypothalamic-pituitary-adrenal (HPA) axis and related hormone
levels, including adrenocorticotropin (ACTH), cortisol,
arginine vasopressin (AVP), and neuropeptide Y (NPY), in
patients with fibromyalgia (FM).

METHODS. Basal and ovine
corticotropin-releasing hormone (oCRH)-stimulated HPA axis
function were assessed in 12 patients with FM and in age- and
sex-matched normal subjects. Basal plasma AVP levels and AVP
release after postural change were assessed, and plasma NPY
levels ["colocalizes w norepinephrine and stimulated
peripherally during stress"] were measured in the same
samples.

RESULTS. Patients with FM had low 24-hour urinary
free cortisol, but normal peak [i.e., at 0800] and elevated
trough [i.e, at2000] plasma cortisol levels, compared with
normal subjects. The net integrated ACTH response to oCRH in
FM was not significantly different from that in normal
subjects, but tended toward an exaggerated response. There was
a significant decrease in net integrated cortisol response to
oCRH in FM patients, indicating adrenal hyporesponsiveness.
AVP levels were not significantly different between FM
patients and control subjects, but variability was greater
among the FM patients. Plasma NPY levels were significantly
lower in FM patients than in normal subjects.

CONCLUSION. These data support the view that HPA axis
function is perturbed in patients with FM. Further study is
required to ascertain the cause of HPA axis perturbations and
their relationship to symptoms in patients with FM.

Crofford LJ, Pillemer SR, Kalogeras KT, Cash JM, Michelson D, Kling
MA, Sternberg EM, Gold PW, Chrousos GP, Wilder RL




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Safely Burn Away Body Fat Safely Burn Away Body Fat
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map