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Fatigue syndromes revisited: the possible role of porphyrins

  [ 25 votes ]   [ Discuss This Article ] • May 3, 1994

The author sees many patients with chronic oral problems of unknown
etiology. It has been noticed that many of these patients also
have complex medical histories. Fatigue and pain are two of
the most common features observed. Some, but not all, also
have other definitive medical diagnoses. Those patients with
appropriate symptoms have been tested for porphyrins and
porphyrin enzyme activity. Advances in molecular biology have
led to the availability of a number of porphyrin enzymes for
routine testing. The results are interesting and suggest
abnormal porphyrin metabolism may be more prevalent than is
currently thought.

Downey DC

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