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Somatomedin C (insulin-like growth factor 1) levels decrease during acute changes of stress related hormones. Relevance for fibromyalgia (FM)

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www.ProHealth.com • July 2, 1994


OBJECTIVE. To determine the effects of stress hormones on
insulin-like growth factor 1 (IGF-1).

METHODS. Insulin induced
hypoglycemia (< 3 mmol/l) and clonidine induced depression of
noradrenergic tone were used to assess the acute effects of
cortisol, human growth hormone (hGH), and norepinephrine (NE).

RESULTS. Despite the increase of hGH during hypoglycemia, a
statistically significant decrease of IGF-1 was observed along
with the expected rise of cortisol and NE. To eliminate the
role played by NE, NE tone was depressed by administering
clonidine. A statistically significant decrease of IGF-1 was
also observed.

CONCLUSION. Acute cortisol release or a NE
decrease induce low IGF-1 levels. {MCMStrSt}

Ferraccioli G, Guerra P, Rizzi V, Baraldo M, Salaffi F, Furlanut M,
Bartoli E




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