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Eicosanoids & essential fatty acid modulation in chronic disease & the Chronic Fatigue Syndrome (CFS)

  [ 96 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 3, 1994


Abnormalities of Essential Fatty Acid (EFA) incorporation into
phospholipid are found in chronic diseases. More recently
changes in circulating EFA metabolites (EFAM) together with
EFAM hypo-responsiveness of immune cells and EFAM production
from cells have been found associated with disease. We
hypothesize that changes in ratio of EFAMs are the normal
physiological responses to stressors, but when stressors are
excessive or prolonged, EFAM systems may become unpredictably
hypo-responsive owing to factors such as receptor down
regulation and substrate depletion. In time, many homeostatic
system become deranged and held in that state by minor
stressors. Literature review of chronic fatigue syndrome (CFS)
shows hyper and hypo-responsiveness in immune function,
several Hypothalamo-Pituitary (HP) axes and sympathetic
nervous system, all relatable to dysfunctional changes in EFA
metabolism. For the first time, we explain chronic immune
system activation and hypo-responsive immune function in CFS;
through EFAMs. Dietary EFA modulation (DEFA) can alter ratios
of both membrane EFAs and produced EFAMs, and if maintained
can restore hypo-responsive function. We discuss dietary
strategies and relevance in CFS, and a case series of CFS
patients applying DEFA with other titrated published
managements which saw 90% gaining improvement within 3 months
and more than 2/3 fit for full time duties. This hypothesis
and DEFA may have relevance in other chronic conditions.

Gray JB, Martinovic AM




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