ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Lutein — An Important Nutrient for Eye and Brain Health

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

Lutein, found in leafy greens, may counter cognitive aging

Vitamin D3 Versus D2

 
Print Page
Email Article

Study: Second-Generation Antidepressants Similar, But Have Different Side Effects

  [ 221 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 26, 2005


News Release By DAVID WILLIAMSON
UNC News Services Source: The University of North Carolina at Chapel Hill CHAPEL HILL – Because clinical depression is so disabling and affects more than 16 percent of adults in the United States at some time in their lives, researchers have worked hard to develop more effective treatments. But how much better are the newer pharmaceuticals? Many second-generation antidepressants, despite differences in drug classification and cost, offer patients essentially the same benefits with little variation in risks, University of North Carolina at Chapel Hill researchers have found. Such antidepressants include selective serotonin reuptake inhibitors (SSRIs) and other drugs that affect the activity of neurotransmitters in a selective way. In a paper published online today (Sept. 19) and to be published in the October issue of the journal Annals of Internal Medicine, Dr. Richard A. Hansen and colleagues examined the effects of 10 commonly prescribed second-generation antidepressants. Those drugs included familiar brand-name drugs such as Prozac, Zoloft, Effexor, Wellbutrin and Paxil. Hansen is assistant professor of pharmacy at the UNC School of Pharmacy. The study he led involved investigating the medications’ role in the initial treatment of adults suffering from major depression by combining and systematically analyzing data from 46 randomized, controlled trials. Other authors, all at UNC, are Drs. Gerald Gartlehner and Timothy S. Carey of the Cecil G. Sheps Center for Health Services Research, Dr. Kathleen N. Lohr of the health policy and administration department at the School of Public Health, and Bradley N. Gaynes of the School of Medicine’s psychiatry department. Carey, professor of medicine, directs the Sheps Center. Gartlehner is associate director of the RTI-UNC Evidence-based Practice Center. "Past studies have compared the effectiveness of second-generation antidepressants with that of placebo or older treatments but have not systematically evaluated how the second-generation agents compared to each other," Hansen said. "Given the number of second-generation treatments available, cost differences, widespread use and the general lack of consensus in how the drugs compare, our research can help patients, clinicians and policy makers decide which drug is best." The bottom line was that one was about as good as another in terms of effectiveness, but the likelihood that patients experienced certain side effects differed between compounds, he said. "Comparative evidence on these drugs suggests that there are only minimal differences in efficacy, although some of the drugs come with an increased risk of certain side effects," Hansen said. "Understanding the likelihood of the side effects and matching this information with patients’ lifestyle and preferences for anticipated side effects may help improve drug treatment of depression. "Although our study did not specifically assess the impact of drug costs or differences in dosing regimens on how patients fared, those factors also may be important determinants in drug selection," the scientist said. "That’s in the absence of patient preference or a clear choice for which agent is best for a given person." Limitations of the study were that published data from some trials was not as complete and comparable as researchers would have preferred, Hansen said. Most data was from trials sponsored by drug companies, and questions remain as to how unbiased such studies are. Support for the investigation came to the Cecil G. Sheps Center for Health Services Research from the Drug Effectiveness Review Project, a collaborative program coordinated by the Center for Evidence-Based Policy at the Oregon Health and Science University. In 2000, the economic burden of depression was estimated to be $83.1 billion, Hansen said. Although drug treatment does not work for all patients, drugs are usually considered the first and potentially best treatment in part since primary care physicians prescribe the majority of antidepressants in this country. School of Pharmacy contact: Kara Brewer, (919) 843-9248 or kara_brewer@unc.edu News Services contact: David Williamson, (919) 962-8596



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® FibroSleep™ Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map