ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

More evidence for calorie restriction’s longevity effect

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

Print Page
Email Article

Experts Highlight Strategies to Raise 'Good' HDL Cholesterol

  [ 323 votes ]   [ Discuss This Article ] • October 10, 2005

The newspaper of The Johns Hopkins University
September 26, 2005, Vol. 35 No. 4 By David March Johns Hopkins Medicine Cardiology experts at Johns Hopkins have issued interim guidelines for physicians on how best to treat low levels of HDL cholesterol, the so-called good cholesterol, which helps keep arteries clear from the buildup of LDL cholesterol, the so-called bad cholesterol. More than 54 million Americans are estimated to need higher levels of HDL, according to the American Heart Association. In an article published in The New England Journal of Medicine online Sept. 22, the Johns Hopkins researchers report that existing strategies to prevent heart disease have not addressed the best means to raise HDL cholesterol and instead have focused heavily on lowering LDL cholesterol, which leads to plaque formation and narrowing of the arteries that can cause heart attack. "We have reached a turning point in the prevention of coronary heart disease, from an emphasis during the last 15 years on lowering LDL cholesterol levels to an emphasis in the next decade on raising levels of HDL cholesterol," said article lead author and cardiologist Roger Blumenthal, an associate professor and director of the Ciccarone Preventive Cardiology Center at the School of Medicine and its Heart Institute. Existing guidelines from the U.S. National Institutes of Health and its National Cholesterol Education Program primarily emphasize lowering LDL cholesterol to control blood lipid levels without considering the alternative of raising HDL cholesterol as the primary or even secondary goal, Blumenthal said. However, Blumenthal said, every single milligram per deciliter increase in HDL cholesterol lowers a person's risk of suffering a fatal heart attack by about 3 percent; low levels of HDL cholesterol are known to increase overall risk of dying from heart disease and, specifically, to increase risk of arteries narrowing again after angioplasty surgery to clear them. Low levels of HDL cholesterol, he said, are defined as less than 40 milligrams per deciliter of blood in men and 50 milligrams per deciliter in women. In the NEJM report, Blumenthal and a fellow expert, nurse practitioner Dominique Ashen, an assistant professor at the School of Nursing, provide a comprehensive review and summary of the 50 most significant research studies on how best to manage people's HDL cholesterol levels through modification of lifestyle risk factors for developing heart disease and use of drug therapy. In addition, the researchers support their summary findings with a concise table listing heart medications with guidelines about how and when the drugs — niacin, fibrates and statins, or various combinations — can be used to raise HDL cholesterol levels. Also provided in the table are details on the drugs' chemical properties, or mechanism of action, and possible side effects. However, Blumenthal and Ashen pointed out that research to date has not yet clearly distinguished which reductions in risk from heart disease are due to drug gains in HDL levels or other direct effects on the arteries. "That has been responsible for delaying revisions to national guidelines on HDL cholesterol," Blumenthal said. Using a recent patient case study from Johns Hopkins involving a 41-year-old man with low levels of HDL cholesterol (28 milligrams per deciliter), the researchers reviewed how over a period of three years his HDL levels were raised to above normal by modifying his lifestyle risk factors. These modifications included making sure the patient engaged in regular exercise, ceased smoking, assumed control over his weight as measured by body mass index, limited alcohol intake and monitored dietary fat intake. The patient lost nearly 50 pounds while undergoing treatment. To raise HDL cholesterol levels, the researchers recommend a regular exercise program of brisk aerobic exercise for 30 minutes several times per week, if not every day. Quitting smoking, they said, provides an average increase in HDL levels of 4 milligrams per deciliter. Aids such as drug therapy, nicotine replacement products and counseling can help patients quit. Weight control is also highlighted as critical to raising HDL levels, with the researchers noting that every kilogram of weight lost raises a patient's HDL levels by an average 0.35 milligrams per deciliter. A reasonable weight loss goal for overweight or obese patients, they suggest, is one pound per week, with a target body mass index of less than 25. Mild to moderate consumption of alcohol, no more than one to two drinks per day, they said, has been shown to be beneficial in raising HDL levels by an average of 4 milligrams per deciliter, irrespective of type of alcohol consumed. But the researchers cautioned that the potential risks here may outweigh the benefits in people with liver or addiction problems. For dietary control, the researchers recommend a diet low in saturated fat and rich in the polyunsaturated fatty acids found in foods such as oils (olive, canola, soy and flaxseed), nuts (almonds, peanuts, walnuts and pecans), cold-water fish (salmon and mackerel) and shellfish. Consumption of carbohydrates, they say, should be restricted because high glycemic products, such as processed cereals and breads, are associated with lower HDL levels. In the report, the researchers cite niacin, also called nicotinic acid or vitamin B3, as the most effective medication for raising HDL cholesterol, leading to increases of 20 percent to 35 percent. Fibrate therapy is also effective, they said, producing an average increase of 10 percent to 25 percent. Statins are the least effective of the three drug classes, used primarily to reduce LDL cholesterol, raising HDL levels by 2 percent to 15 percent. When used in combination, low-dose statins and high-dose niacin have been shown to produce benefits of 21 percent to 26 percent. "Our report offers people interim guidelines on how best to manage HDL cholesterol levels while awaiting the results of national clinical trials, which could prove more definitive," said Ashen, who was lead author of the article. "These guidelines also offer a good description of the problem posed by low levels of HDL cholesterol, along with details on how HDL cholesterol metabolism works in the body with LDL cholesterol. The guidelines, she said, "should help physicians and nurses to manage their patients' blood lipid levels, including HDL cholesterol, with drug therapies currently available, and should help prepare them to manage future therapies, expected to be developed within the next five years, that focus on raising HDL-cholesterol levels." Funding support for the researchers was provided by the Maryland Athletic Club & Wellness Center Charitable Foundation.

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map