ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Cassia Bark Oil: Why It's Valuable in Traditional Chinese Medicine

Hormone replacement therapy associated with lower risk of dying over eight year follow-up period

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

 
Print Page
Email Article

A comparative study on antibodies to nucleoli & 5-hydroxytryptamine in patients with fibromyalgia (FM) syndrome & tryptophan-induced eosinophilia-myalgia syndrome

  [ 66 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 3, 1994


Eosinophilia myalgia syndrome (EMS) has been related to intake of
"contaminated" L-tryptophan, and an alteration in tryptophan
5-hydroxytryptamine (5-HT, serotonin) metabolism has been
reported in EMS patients. Recently we found that a defined
autoantibody pattern consisting of antibodies to nucleoli,
gangliosides, and phospholipids is closely related to the
fibromyalgia syndrome (FS) which clinically resembles the EMS.
We were therefore interested to see whether these antibodies
can also be detected in patients with EMS. Studied were 27
patients with acute EMS (13 of whom were also examined 2 years
after acute onset), 100 patients with FS, and 40 patients with
progressive systemic sclerosis (PSS). As controls, sera from
100 blood donors were analyzed. Antibodies to nucleoli were
demonstrated by immunofluorescence test on cell cultures in
52% of patients with acute EMS, 62% of patients with chronic
EMS, and 37% of FS patients. Western blotting with a nuclear
extract from HeLa cells revealed in both diseases the same
epitopes at 63, 57, and 53 kDa. Antibodies to 5-HT,
gangliosides (Gm1), and phospholipids were determined by
enzyme-linked immunosorbent assay. Among patients with FS 73%
had antibodies to 5-HT, in contrast to only 19% of patients
with acute EMS. However, 77% of the 13 EMS patients analyzed 2
years later had become anti-5-HT antibody positive during that
time. Also the incidence of antibodies to Gm1 increased from
37% at acute onset to 69% in patients with chronic EMS (30%).
The various antibodies were detected in only 18% of healthy
controls.

Klein R, Berg PA




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map