ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Eating more vegetable protein may protect against early menopause

Is Activated Charcoal Beneficial?

German Chamomile Oil: A Versatile Essential Oil You Should Have at Home

 
Print Page
Email Article

A comparative study on antibodies to nucleoli & 5-hydroxytryptamine in patients with fibromyalgia (FM) syndrome & tryptophan-induced eosinophilia-myalgia syndrome

  [ 66 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 3, 1994


Eosinophilia myalgia syndrome (EMS) has been related to intake of
"contaminated" L-tryptophan, and an alteration in tryptophan
5-hydroxytryptamine (5-HT, serotonin) metabolism has been
reported in EMS patients. Recently we found that a defined
autoantibody pattern consisting of antibodies to nucleoli,
gangliosides, and phospholipids is closely related to the
fibromyalgia syndrome (FS) which clinically resembles the EMS.
We were therefore interested to see whether these antibodies
can also be detected in patients with EMS. Studied were 27
patients with acute EMS (13 of whom were also examined 2 years
after acute onset), 100 patients with FS, and 40 patients with
progressive systemic sclerosis (PSS). As controls, sera from
100 blood donors were analyzed. Antibodies to nucleoli were
demonstrated by immunofluorescence test on cell cultures in
52% of patients with acute EMS, 62% of patients with chronic
EMS, and 37% of FS patients. Western blotting with a nuclear
extract from HeLa cells revealed in both diseases the same
epitopes at 63, 57, and 53 kDa. Antibodies to 5-HT,
gangliosides (Gm1), and phospholipids were determined by
enzyme-linked immunosorbent assay. Among patients with FS 73%
had antibodies to 5-HT, in contrast to only 19% of patients
with acute EMS. However, 77% of the 13 EMS patients analyzed 2
years later had become anti-5-HT antibody positive during that
time. Also the incidence of antibodies to Gm1 increased from
37% at acute onset to 69% in patients with chronic EMS (30%).
The various antibodies were detected in only 18% of healthy
controls.

Klein R, Berg PA




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map