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Clinical correlates of infection with human herpesvirus-6

  [ 17 votes ]   [ Discuss This Article ] • July 3, 1994

Human herpesvirus-6 is a lymphotropic virus which infects
susceptible individuals during the first year of life and
usually causes life-long latency. In a variable percentage
primary infections are followed by a short acute disease,
exanthema subitum. Older individuals may suffer from
infectious mononucleosis-like illnesses or from
Kikuchi-Fujimoto's disease. In addition, there is a fairly
wide spectrum of lymphoid and hematopoietic diseases or
autoimmune disorders, which are associated with elevated
titers of HHV-6 antibody, and from which replicating virus may
be isolated. Such diseases include atypical polyclonal
lymphoproliferation, Hodgkin's disease, chronic fatigue
syndrome and systemic lupus erythematosus. The present article
reviews the current knowledge of such associations.

Krueger GR, Klueppelberg U, Hoffmann A, Ablashi DV

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