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High titers of anti-Epstein-Barr virus DNA polymerase are found in patients with severe fatiguing illness

  [ 18 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 3, 1994


Forty-one patients with chronic fatigue syndrome (CFS), 76 healthy
controls matched with the patient group for age range, sex,
race, and socioeconomic class, and 22 symptomatic patients
with seasonal affective disorder (SAD) had serum sampled for
antibodies against 2 Epstein-Barr virus (EBV) replicating
enzymes. Abnormal titers of antibodies were found twice as
often in CFS patients as controls (34.1% vs. 17.1%), with SAD
patients having an intermediate frequency (27.3%). Stratifying
for disease severity sharpened the differences considerably,
with the sicker CFS and SAD patients having 52% and 50%
abnormal tests, respectively; more mildly afflicted CFS and
SAD patients had a frequency of abnormal tests in the normal
range. Antibodies to EBV DNA polymerase (DNAP) were the more
sensitive of the two tests in that they were positive in all
cases but one. These findings suggest that antibodies against
EBV DNAP may be a useful marker in delineating a subset of
patients with severe fatiguing illness for appropriate
treatment trials and for monitoring their outcomes.

Natelson BH, Ye N, Moul DE, Jenkins FJ, Oren DA, Tapp WN, Cheng YC




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